Evidence map›Paper›PMID 41574278›Full record

ArticleNeuroscience of consciousness2026

Evaluating Alzheimer's disease with the TMS-EEG perturbation complexity index.

Brenna Hagan, Stephanie S Buss, Peter J Fried, Mouhsin M Shafi, Katherine W Turk, Kathy Y Xie, Brandon Frank, Brice Passera, Recep Ali Ozdemir, Andrew E Budson

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience of consciousness, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03875638 (Treating Hyperexcitability in Alzheimer's Disease With Levetiracetam to Improve Brain Function and Cognition), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03875638 phase2completednot on this map

Treating Hyperexcitability in Alzheimer's Disease With Levetiracetam to Improve Brain Function and Cognition

TypeinterventionalSponsorBeth Israel Deaconess Medical CenterRan2019 to 2026Enrolled58ConditionsAlzheimer Dementia, Alzheimer Disease, Dementia of Alzheimer Type, Mild Cognitive ImpairmentArmsLevetiracetam, Placebo oral capsule
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brenna HaganCenter for Translational Cognitive Neuroscience, VA Boston Healthcare System, 150 S. Huntington Ave, Boston, MA 02130, United States.ORCID https://orcid.org/0009-0004-7830-0780
Stephanie S BussBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, United States.
Peter J FriedBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, United States.
Mouhsin M ShafiBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, United States.ORCID https://orcid.org/0000-0002-4531-1967
Katherine W TurkCenter for Translational Cognitive Neuroscience, VA Boston Healthcare System, 150 S. Huntington Ave, Boston, MA 02130, United States.
Kathy Y XieCenter for Translational Cognitive Neuroscience, VA Boston Healthcare System, 150 S. Huntington Ave, Boston, MA 02130, United States.
Brandon FrankCenter for Translational Cognitive Neuroscience, VA Boston Healthcare System, 150 S. Huntington Ave, Boston, MA 02130, United States.ORCID https://orcid.org/0000-0002-0548-9074
Brice PasseraBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, United States.
Recep Ali OzdemirBerenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, United States.ORCID https://orcid.org/0000-0003-2832-1300
Andrew E BudsonCenter for Translational Cognitive Neuroscience, VA Boston Healthcare System, 150 S. Huntington Ave, Boston, MA 02130, United States.ORCID https://orcid.org/0000-0002-2913-0015

Funding

The Role of Inflammation in the Pathophysiology of Delirium and its Associated Long-Term Cognitive DeclineP01AG031720 · NIA · HEBREW REHABILITATION CENTER FOR AGED · PI INOUYE, SHARON K. · 2010 to 2022
$26.7M
Repetitive TMS-induced modulation of cortical excitability in ADR01MH115949 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAFI, MOUHSIN · 2018 to 2022
$3.2M
Treating hyperexcitability in Alzheimer’s disease with levetiracetam to improve brain function and cognitionR01AG060987 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAFI, MOUHSIN · 2019 to 2023
$3.0M
Enhancing robotic head and neck surgical skills using stimulated simulationR01EB032820 · NIBIB · FLORIDA STATE UNIVERSITY · PI Suvranu De, Ernest Dennis Gomez · 2023 to 2026
$1.8M
CSRD VA I01 CX002400CSRD VA IK2 CX002065CSRD VA IK2 CX002625NIA NIH HHS P01 AG031720NIA NIH HHS R01 AG060987NIBIB NIH HHS R01 EB032820NIMH NIH HHS R01 MH115949
6 · The paper itself

Abstract

The Perturbation Complexity Index-State Transitions (PCI

Indexed as

Alzheimer's diseaseConsciousnessNeurologyPCITMS-EEG

Identifiers

PMID41574278
PMCPMC12821375

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.