Evidence map›Paper›PMID 41574275›Full record

ArticleOxford open immunology2026

Comparative analysis of malignant pleural effusion and peripheral blood reveals unique T cell signatures associated with survival in mesothelioma patients.

Nicola Principe, Kofi L P Stevens, Amber-Lee Phung, Melanie McCoy, Joel Kidman, Ali Ismail, Alistair M Cook, Abha Chopra, Mark Watson, Bruce W Robinson and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxford open immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Nicola PrincipeInstitute for Respiratory Health, National Centre for Asbestos Related Diseases, University of Western Australia, Perth, WA, 6000, Australia.ORCID https://orcid.org/0000-0001-6458-2482
Kofi L P StevensInstitute for Respiratory Health, National Centre for Asbestos Related Diseases, University of Western Australia, Perth, WA, 6000, Australia.
Amber-Lee PhungInstitute for Respiratory Health, National Centre for Asbestos Related Diseases, University of Western Australia, Perth, WA, 6000, Australia.
Melanie McCoyColorectal Cancer Research Unit, St John of God Subiaco Hospital, Subiaco, WA, 6008, Australia.
Joel KidmanInstitute for Respiratory Health, National Centre for Asbestos Related Diseases, University of Western Australia, Perth, WA, 6000, Australia.
Ali IsmailMedical School, University of Western Australia, Crawley, WA, 6009, Australia.
Alistair M CookInstitute for Respiratory Health, National Centre for Asbestos Related Diseases, University of Western Australia, Perth, WA, 6000, Australia.
Abha ChopraIIID Laboratory, Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, WA, 6150, Australia.
Mark WatsonIIID Laboratory, Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Murdoch, WA, 6150, Australia.
Bruce W RobinsonInstitute for Respiratory Health, National Centre for Asbestos Related Diseases, University of Western Australia, Perth, WA, 6000, Australia.
Jenette CreaneyInstitute for Respiratory Health, National Centre for Asbestos Related Diseases, University of Western Australia, Perth, WA, 6000, Australia.
Y C Gary LeeDepartment of Respiratory Medicine, Sir Charles Gairdner Hospital, Perth, WA, 6000, Australia.
Jason WaithmanSchool of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.
W Joost LesterhuisSchool of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.
Richard A LakeInstitute for Respiratory Health, National Centre for Asbestos Related Diseases, University of Western Australia, Perth, WA, 6000, Australia.
Anna K NowakInstitute for Respiratory Health, National Centre for Asbestos Related Diseases, University of Western Australia, Perth, WA, 6000, Australia.
Jonathan CheeInstitute for Respiratory Health, National Centre for Asbestos Related Diseases, University of Western Australia, Perth, WA, 6000, Australia.
Alison M McDonnellSchool of Biomedical Sciences, University of Western Australia, Crawley, WA, 6009, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The success of cancer immunotherapies has highlighted the importance of monitoring the anti-tumour T cell response. Patients with mesothelioma frequently present with a malignant pleural effusion (MPE) that is commonly drained regularly to alleviate symptoms. As MPE contains tumour cells, T cells and cytokines, it provides a unique opportunity to sample immune events at the tumour site. However, there is minimal information on how MPE T cells are distinct from those in the blood, and whether T cell phenotypes unique to each compartment correlate with survival. We characterised T cell populations of matched MPE and blood from 31 mesothelioma patients using flow cytometry and bulk T cell receptor beta (TCRβ) sequencing. MPE CD8

Indexed as

CD8+ T cellsmalignant pleural effusionmesotheliomaTCR sequencingtissue resident memory T cells

Identifiers

PMID41574275
PMCPMC12823008

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.