ArticleFrontiers in veterinary science2025
Functional toll-like receptor 4 links endotoxin sensing to platelet priming in feline platelets.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To characterize toll-like receptor 4 (TLR4) expression in feline platelets and to assess the priming potential of Methods: Eighteen healthy staff- and student-owned cats were enrolled. Washed platelets prepared from whole blood were analyzed for total and surface TLR4 expression using Western blotting, flow cytometry, and super-resolution immunofluorescence microscopy in the presence or absence of stimulation. The priming potential of LPS was evaluated by measuring alpha-granule secretion by P-selectin expression and thromboxane B Results: Thrombin stimulation significantly upregulated both surface and total platelet TLR4 expression. While LPS alone did not induce α-granule secretion with or without ADP, it reversed the inhibitory effect of AA by enhancing P-selectin expression and potentiating TxB Discussion: This study is the first to demonstrate functional TLR4 expression in feline platelets. Activation of TLR4 sensitizes platelets to AA by augmenting TxA
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