Evidence map›Paper›PMID 41574175›Full record

ArticleOpen forum infectious diseases2026

Controlled Human Infection of Healthy Adults With Lyophilized

D F Gbesemete, F Haidara, J R Laver, M Ibrahim, J MacLennan, A P Dale, A R Gorringe, Y Traore, F Diallo, H Badji and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

D F GbesemeteControlled Human Infection Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0001-7539-9069
F HaidaraCentre pour les Vaccins en Développement - Mali, Bamako, Mali.ORCID https://orcid.org/0000-0003-1121-2941
J R LaverControlled Human Infection Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0003-3314-5989
M IbrahimControlled Human Infection Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0002-4011-2424
J MacLennanDepartment of Zoology, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0003-0973-2809
A P DaleControlled Human Infection Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0001-8163-7481
A R GorringeUnited Kingdom Health Security Agency, Porton Down, Salisbury, UK.ORCID https://orcid.org/0000-0003-2193-7954
Y TraoreCentre pour les Vaccins en Développement - Mali, Bamako, Mali.
F DialloCentre pour les Vaccins en Développement - Mali, Bamako, Mali.
H BadjiCentre pour les Vaccins en Développement - Mali, Bamako, Mali.
A TraoreCentre pour les Vaccins en Développement - Mali, Bamako, Mali.
U OnwuchekwaCentre pour les Vaccins en Développement - Mali, Bamako, Mali.ORCID https://orcid.org/0000-0003-1677-269X
E JonesControlled Human Infection Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
C WebbControlled Human Infection Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0001-6401-4397
J GuyControlled Human Infection Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0001-9176-6092
A A TheodosiouControlled Human Infection Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0002-0096-4825
S N FaustNIHR Southampton Biomedical Research Centre and NIHR Southampton Clinical Research Facility, University Hospital Southampton, Southampton, UK.
S O SowCentre pour les Vaccins en Développement - Mali, Bamako, Mali.ORCID https://orcid.org/0000-0002-6335-5066
R S HeydermanNIHR Global Health Research Unit on Mucosal Pathogens, Division of Infection & Immunity, University College London, London, UK.ORCID https://orcid.org/0000-0003-4573-449X
M D TapiaCenter for Vaccine Development and Global Health, University of Maryland, School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-6476-3934
R C ReadControlled Human Infection Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID https://orcid.org/0000-0002-4297-6728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Carriage of Methods: Healthy adult volunteers aged 18-45 years were inoculated intranasally with 10 Results: Intranasal inoculation with LyoNlac was well tolerated with no significant safety concerns. In the United Kingdom, 10 Conclusions: Intranasal inoculation with LyoNlac was safe and induced immunogenic nasopharyngeal colonization in healthy adults in the United Kingdom and Mali. Future clinical trials to determine whether LyoNlac reduces meningococcal carriage and transmission in the meningitis belt are warranted.

Indexed as

African meningitis beltcontrolled human infectionlyophilizationNeisseria lactamicaNeisseria meningitidis

Identifiers

PMID41574175
PMCPMC12822493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.