ArticleNorthern clinics of Istanbul2025
The role of red cell distribution width in predicting 7-day in-hospital mortality in patients with acute ischemic stroke.
Article in Northern clinics of Istanbul, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveRed cell distribution width (RDW) is a hematological parameter that is routinely obtained as part of the complete blood count analysis. An increased RDW level, which helps identify erythrocyte anisocytosis, is also a good indicator of the severity and outcome of some other diseases. The aim of this study was to investigate the predictive power of the serum RDW level for determining (seven-days mortality) of patients with acute ischemic stroke (AIS).
methodsA total of 527 adult patients with AIS presenting to our emergency department of tertiary-care hospital were retrospectively enrolled. The baseline characteristics, National Institute of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores, reflecting stroke severity and neurological outcome, and serum RDW values were recorded retrospectively. An univariate and multivariate logistic regression analyses were performed to identify independent predictors of seven-days mortality, including serum levels of RDW, age, NIHSS and mRS values.
resultsSerum RDW levels were significantly lower in patients who survived longer than seven-day compared with those who died within the first seven-days (15.36±1.04% v.s 16.61±1.28%, p=0.001). Furthermore, the mean NIHSS score was significantly lower in patients who survived longer than seven-days compared with those who died within the first seven-days. Additionally, the mean mRS score was significantly lower in patients who survived longer than seven-day compared with those who died within the first seven-day (p=0.001). Receiving operator characteristic analysis revealed a cut-off RDW level of 16.2%, with 66.1% sensitivity and 78% specificity, for distinguishing patients who survived longer than seven-days from who died within the first seven-day.
conclusionThe serum RDW level may serve as a guide in diagnostic decision-making to predict neurological outcome and determine the short-term survival of patients with AIS.
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