Evidence map›Paper›PMID 41574117›Full record

ArticleCHEST critical care2025

Ascorbate for Organ Dysfunction in Critically Ill Patients With Sepsis: The Phase 2b ASTER Trial.

D Clark Files, Michael A Matthay, Lorraine B Ware, Roy G Brower, Neil R Aggarwal, Samuel M Brown, Steven Y Chang, Ivor S Douglas, Abhijit Duggal, Kevin W Gibbs and 22 more

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Article in CHEST critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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32 authors.

D Clark FilesWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Michael A MatthayWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Lorraine B WareWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Roy G BrowerWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Neil R AggarwalWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Samuel M BrownWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Steven Y ChangWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Ivor S DouglasWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Abhijit DuggalWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Kevin W GibbsWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Scott FieldsWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Andrea S FoulkesWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Adit GindeWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Andrew GoodwinWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Estelle S HarrisWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Gregory W HendeyWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Kathryn HibbertWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

R Duncan HiteWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Catherine L HoughWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Weixing HuangWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Akram KhanWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Poying LaiWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Kathleen D LiuWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Chadwick MillerWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Ari MoskowitzWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Richard RikerWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Bryce R H RobinsonWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Wesley H SelfWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Mark A TidswellWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Donald M YealyWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

B Taylor ThompsonWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Alpha A FowlerWake Forest University School of Medicine (D. C. F., K. W. G., and C. M.), Winston-Salem, NC; the University of California, San Francisco (M. A. M. and S. F.), San Francisco, the University of California, Los Angeles (S. Y. C., G. W. H., and K. D. L.), Los Angeles, CA; the Vanderbilt University Medical Center (L. B. W. and W. H. S.), Nashville, TN; the Johns Hopkins Hospital (R. G. B.), Baltimore, MD; the University of Colorado (N. R. A. and A. G.), the Denver Health Medical Center (I. S. D.), Denver, CO; Intermountain Health (S. M. B.), the University of Utah (E. S. H.), Salt Lake City, UT; the Cleveland Clinic (A. D.), Cleveland, the University of Cincinnati (R. D. H.), Cincinnati, OH; the Massachusetts General Hospital (A. S. F., K. H., W. H., P. L., and B. T. T.), Boston; the Baystate Medical Center (M. A. T.), Springfield, MA; the Medical University of South Carolina (A. G.), Charleston, SC; the Oregon Health and Science University (C. L. H. and A. K.), the Maine Medical Center (R. R.), Portland, OR; the Mount Sinai Hospital (A. M.), New York, NY; the Harborview Medical Center (B. R. H. R.), University of Washington, Seattle, WA, the University of Pittsburgh Medical Center (D. M. Y.), Pittsburgh, PA; and the Virginia Commonwealth University (A. A. F.), Richmond, VA.

Funding

CCC for NHLBI Prevention and Early Treatment of Acute Lung Injury PETAL NetworkU01HL123009 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI FOULKES, ANDREA S, THOMPSON, BOYD TAYLOR · 2014 to 2021

$67.2M

Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute LungU01HL123022 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAPIRO, NATHAN I, TALMOR, DANIEL STUART · 2014 to 2020

$2.9M

Prevention and Early Treatment of Acute Lung InjuryU01HL123004 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHAY, MICHAEL A. · 2014 to 2020

$2.6M

Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute LungU01HL123031 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HYZY, ROBERT C, PARK, PAULINE K · 2014 to 2020

$2.6M

Enhancing the Surrogate Informed Consent Process for Critical Care ResearchU01HL123010 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI GINDE, ADIT A., MOSS, MARC · 2014 to 2020

$2.6M

Prevention and Early Treatment of Acute Lung Injury Clinical Trials NetworkU01HL123033 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICE, TODD W · 2014 to 2020

$2.4M

Preventive and Early Treatment of Acute Lung Injury Clinical Trials Network- Pgh - SupplementU01HL123020 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANGUS, DEREK C, YEALY, DONALD M · 2014 to 2020

$2.4M

Long Term Outcomes and Macrophage Biology in Patients with EVALIU01HL123018 · NHLBI · IHC HEALTH SERVICES, INC. · PI BLEDSOE, JOSEPH R, BROWN, SAMUEL MORRIS · 2014 to 2020

$2.4M

Pacific Northwest Clinical Center for the NHLBI PETAL NetworkU01HL123008 · NHLBI · UNIVERSITY OF WASHINGTON · PI HOUGH, CATHERINE LEE, ROBINSON, BRYCE · 2014 to 2020

$2.3M

Acute Lung Injury Group New England Program to Support PETAL Network ResearchU01HL122989 · NHLBI · BAYSTATE MEDICAL CENTER, INC. · PI STEINGRUB, JAY S · 2014 to 2020

$2.2M

Einstein PETAL: Clinical Center for the PETAL NetworkU01HL122998 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GONG, MICHELLE NG, RICHARDSON, LYNNE D. · 2014 to 2020

$1.9M

Wake Forest Clinical Center for the NHLBI PETAL NetworkU01HL123027 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FILES, DANIEL CLARK, MILLER, CHADWICK DAVID · 2014 to 2020

$1.8M

NHLBI NIH HHS U01 HL122989NHLBI NIH HHS U01 HL122998NHLBI NIH HHS U01 HL123004NHLBI NIH HHS U01 HL123008NHLBI NIH HHS U01 HL123009NHLBI NIH HHS U01 HL123010NHLBI NIH HHS U01 HL123018NHLBI NIH HHS U01 HL123020NHLBI NIH HHS U01 HL123022NHLBI NIH HHS U01 HL123023NHLBI NIH HHS U01 HL123027NHLBI NIH HHS U01 HL123031NHLBI NIH HHS U01 HL123033

6 · The paper itself

Abstract

backgroundA phase 2 trial of high-dose IV ascorbate suggested reduced mortality in patients with ARDS, although trials in sepsis have failed to show clinical benefit. RESEARCH QUESTION: Does IV high-dose ascorbate improve outcomes in patients with sepsis at risk of or with ARDS? STUDY DESIGN AND

methodsIn this phase 2b multicenter randomized placebo-controlled trial, patients with known or suspected infection and either shock or acute hypoxemic respiratory failure were randomized to ascorbate (50 mg/kg IV every 6 hours for 5 days) or a matching placebo. The primary outcome was days alive and free of respiratory, renal, and circulatory organ support to day 28. Secondary outcomes included clinical and biological end points.

resultsAfter enrolling 79 participants, the trial was terminated because of the publication of a separate study of septic shock reporting increased mortality with ascorbate. In the current study, days free of organ support were not different for patients receiving ascorbate compared with those receiving placebo: mean (SD), 20.5 (9.5) days vs 19.0 (10.8) days, respectively (

interpretationAscorbate did not improve days free of organ failure, although no safety concerns were identified in this small study. Ascorbate was shown to reduce a biological marker of inflammation associated with adverse outcomes in sepsis and lung injury.

Indexed as

antioxidantlung injuryvitamin C

Identifiers

PMID41574117

DOI10.1016/j.chstcc.2025.100168

PMCPMC12823136

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.