ArticleClinical Medicine Insights. Oncology2026
Effectiveness and Safety of Atezolizumab Plus Bevacizumab in Unresectable Hepatocellular Carcinoma: A Multicenter, Retrospective Real-World Study in China.
Article in Clinical Medicine Insights. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Emerging Immune-Based Therapeutic Strategies in Hepatocellular Carcinoma.Liver international : official journal of the International Association for the Study of the Liver · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Atezolizumab combined with bevacizumab (Atezo + Bev) has received regulatory approval as a first-line systemic therapy for unresectable hepatocellular carcinoma. This study aimed to evaluate the effectiveness and safety of atezolizumab combined with bevacizumab (Atezo + Bev) in treating unresectable hepatocellular carcinoma (uHCC) in a real-world Chinese population, focusing on both first-line and second-line treatment settings. Methods: In this multicenter, retrospective study, patients with uHCC treated with Atezo + Bev were included at 5 centers in China from Jan. 2021 to Jan. 2023. Treatment efficacy was assessed using RECIST 1.1 and mRECIST criteria. Overall response (ORR), disease control rates (DCRs), time to disease progression (TPP), progression-free survival (PFS), and overall survival (OS) were calculated. Results: The study included 48 patients, with a median age of 58 years, among which 35 and 13 patients received Atezo + Bev as first- and second-line treatment, respectively. The ORR and DCR were 39.6% and 70.8% according to RECIST 1.1, and 60.4% and 75.0% according to mRECIST, respectively. With a median follow-up of 14.5 months, the median PFS was 8.5 months (95% CI [4.4, 11.2]) in the first-line treatment group, while in the second-line group it was 5.1 months (95% CI [2.1, 7.9]). The median OS was not reached. Adverse events of any grade were observed in 75% of patients (n = 36), most commonly being thrombocytopenia (27.1%), lymphopenia (25%), and abnormal liver function (14.6%). Conclusion: This study confirmed the practical efficacy and safety of Atezo + Bev in real-world Chinese patients with uHCC, both as a first-line and second-line treatment. Further studies are warranted to validate these findings and optimize treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.