ArticleFrontiers in neuroscience2025
The association of hemoglobin levels and balance function in patients with stroke: a multicenter study in China.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Balance impairment following stroke is a leading cause of disability and falls. Hemoglobin (Hb) affects systemic and cerebral oxygen delivery and may influence neuromuscular function and post-stroke balance, but evidence from large multicenter clinical samples is limited. We investigated the association between hemoglobin concentration and balance performance in a Chinese multicenter cross-sectional study of stroke patients. Methods: We studied 2,006 neuroimaging-confirmed stroke patients from 26 hospitals. Balance impairment was defined as BBS ≤ 40. Admission Hb (g/dL) was analyzed per 1 g/dL and by tertiles (<12.6 g/dL, 12.6-14.0 g/dL, ≥14.0 g/dL). Multivariable logistic regression with sequential adjustment, restricted cubic splines, and prespecified subgroup and sensitivity analyses evaluated associations. Results: Balance impairment occurred in 70.5% (1,414/2,006). Each 1 g/dL higher Hb was associated with lower odds of impairment in unadjusted (OR 0.83, 95% CI 0.78-0.87; Conclusion: Higher admission hemoglobin was independently associated with better balance after stroke. Prospective studies should test whether Hb optimization improves rehabilitation outcomes.
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