Evidence map›Paper›PMID 41574043›Full record

ArticleEuropean heart journal. Digital health2026

A fully automated explainable predictive model for diagnosing pre-capillary and post-capillary pulmonary hypertension on routine unenhanced CT: results from the ASPIRE registry.

Turki Nasser Alnasser, Alireza Hokmabadi, Elliot W Checkley, Michael J Sharkey, Lojain F Abdulaal, Khalid S Alghamdi, Pankaj Garg, Ahmed Maiter, Krit Dwivedi, Mahan Salehi and 7 more

Abstract read
In one paragraph

Article in European heart journal. Digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Turki Nasser AlnasserSchool of Medicine and Population Health, The University of Sheffield, Sheffield S10 2TN, United Kingdom.ORCID https://orcid.org/0009-0004-8014-4924
Alireza HokmabadiSchool of Medicine and Population Health, The University of Sheffield, Sheffield S10 2TN, United Kingdom.
Elliot W CheckleyAcademic Unit of Clinical Radiology, University of Sheffield, Sheffield, United Kingdom.
Michael J SharkeySchool of Medicine and Population Health, The University of Sheffield, Sheffield S10 2TN, United Kingdom.
Lojain F AbdulaalSchool of Medicine and Population Health, The University of Sheffield, Sheffield S10 2TN, United Kingdom.
Khalid S AlghamdiSchool of Medicine and Population Health, The University of Sheffield, Sheffield S10 2TN, United Kingdom.
Pankaj GargNorwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, United Kingdom.
Ahmed MaiterSchool of Medicine and Population Health, The University of Sheffield, Sheffield S10 2TN, United Kingdom.
Krit DwivediSchool of Medicine and Population Health, The University of Sheffield, Sheffield S10 2TN, United Kingdom.
Mahan SalehiSchool of Medicine and Population Health, The University of Sheffield, Sheffield S10 2TN, United Kingdom.
Jonathan Taylor3D Imaging Lab, Sheffield Teaching Hospitals NHSFT, Sheffield, United Kingdom.
Peter Metherall3D Imaging Lab, Sheffield Teaching Hospitals NHSFT, Sheffield, United Kingdom.
Georgia A HydeDepartment of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, United Kingdom.
Ze Ming GohSchool of Medicine and Population Health, The University of Sheffield, Sheffield S10 2TN, United Kingdom.
David G KielySchool of Medicine and Population Health, The University of Sheffield, Sheffield S10 2TN, United Kingdom.
Samer AlabedSchool of Medicine and Population Health, The University of Sheffield, Sheffield S10 2TN, United Kingdom.ORCID https://orcid.org/0000-0002-9960-7587
Andrew J SwiftSchool of Medicine and Population Health, The University of Sheffield, Sheffield S10 2TN, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Unenhanced chest CT is frequently used to assess lung malignancy and parenchymal disease. Harnessing CT data to quantify cardiac and vascular structures has the potential to improve the diagnosis of heart failure and pulmonary hypertension (PH). This study aims to develop a deep learning model to segment and analyse cardiothoracic structures from unenhanced CT images to diagnose PH, pre-capillary PH and PH associated with left heart disease (LHD). Methods and results: A twelve-structure cardiothoracic segmentation model was developed using an institutional cohort ( Conclusion: A fully automated model for multi-structure cardiothoracic segmentation on unenhanced CT is achievable. The model can predict PH and identify patients with pre-capillary PH and PH-LHD with promising performance.

Indexed as

CardiacDeep learningLeft Heart DiseasePulmonary hypertensionSegmentationUnenhanced CT

Identifiers

PMID41574043
PMCPMC12821070

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.