Evidence map›Paper›PMID 41573965›Full record

ArticlebioRxiv : the preprint server for biology2025

Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex.

Blair R K Shevlin, Qi Xiu Fu, Seth R Batten, Brian H Kopell, Arianna Neal Davis, Matthew Heflin, Stephen Heisig, Christopher J Rozell, Ayaka Kato, Kaustubh R Kulkarni and 20 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Blair R K ShevlinCenter for Computational Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-5420-0046
Qi Xiu FuCenter for Computational Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0001-2053-2659
Seth R BattenFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.ORCID 0000-0001-8147-4301
Brian H KopellDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6955-4787
Arianna Neal DavisCenter for Computational Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-8200-8852
Matthew HeflinCenter for Computational Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-0379-3582
Stephen HeisigCenter for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-8096-1730
Christopher J RozellSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0001-5173-1661
Ayaka KatoCenter for Computational Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6306-6600
Kaustubh R KulkarniDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ki Sueng ChoiCenter for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-6446-0677
Ha Neul SongCenter for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Shannon O'NeillDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tanya NauvelDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0001-7185-2337
Isha TrivediCenter for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0009-0004-0654-9886
Jason Patrick WhiteFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.
Terry LohrenzFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.ORCID 0000-0002-1581-0765
Martijn FigeeDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-3679-284X
Thomas TwomeyFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.ORCID 0009-0001-1779-7293
Rosalyn MoranKing's College London, Strand, London, UK.
Dan BangFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.ORCID 0000-0001-7446-7090
Alec E HartleSchool of Neuroscience, Virginia Tech, Blacksburg, VA, USA.ORCID 0000-0002-4089-5473
W Matthew HoweSchool of Neuroscience, Virginia Tech, Blacksburg, VA, USA.
Kenneth T KishidaDepartment of Biology, Wake Forest University, Winston-Salem, NC, USA.ORCID 0000-0002-7394-8922
Leonardo S BarbosaFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.ORCID 0000-0002-2464-8632
Vincenzo G FioreCenter for Computational Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-4865-5482
Ignacio SaezDepartment of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-0651-2069
P Read MontagueFralin Biomedical Research Institute at VTC, Virginia Tech, Roanoke, VA, USA.ORCID 0000-0002-8967-0339
Helen S MaybergCenter for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-1672-2716
Xiaosi GuCenter for Computational Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-9373-987X

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Electrophysiological Biomarkers to Optimize DBS for DepressionUH3NS103550 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MAYBERG, HELEN S, RIVA-POSSE, PATRICIO · 2017 to 2023
$7.7M
Computational and electrochemical substrates of social decision-making in humansR01MH124115 · NIMH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GU, XIAOSI, KISHIDA, KENNETH TUCKER · 2020 to 2024
$5.1M
NCATS NIH HHS UL1 TR004419NIMH NIH HHS R01 MH124115NINDS NIH HHS UH3 NS103550Wellcome Trust
6 · The paper itself

Abstract

Recent advances in deep brain stimulation (DBS) of the subcallosal cingulate (SCC) show promise in mitigating the symptoms of treatment-resistant depression (TRD) in humans

Indexed as

deep brain stimulationdepressionprognostic markerstranslational research

Identifiers

PMID41573965
PMCPMC12822799

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.