Evidence map›Paper›PMID 41573946›Full record

ArticlebioRxiv : the preprint server for biology2025

Rapamycin Differentially Impacts Germline Stem Cell Quiescence Across Diverse Genetic Backgrounds of

Sahiti Peddibhotla, Miriam Gonzaga, Tricia Zhang, Yasha Goel, Jun Sun, Benjamin R Harrison, Daniel E L Promislow, Hannele Ruohola-Baker

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sahiti PeddibhotlaDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Miriam GonzagaDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Tricia ZhangDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Yasha GoelDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Jun SunDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Benjamin R HarrisonDepartment of Anesthesiology and Pain Medicine, UW School of Medicine, Seattle, WA 98195, USA.
Daniel E L PromislowJean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.ORCID 0000-0001-7088-4495
Hannele Ruohola-BakerDepartment of Biochemistry, University of Washington, Seattle, WA 98195, USA.ORCID 0000-0002-5588-4531

Funding

Using metabolomics to identify mechanisms of natural variation in agingR56AG049494 · NIA · UNIVERSITY OF WASHINGTON · PI PROMISLOW, DANIEL EDWARD, VILLEN, JUDIT · 2022 to 2022
$319k
NIA NIH HHS R56 AG049494
6 · The paper itself

Abstract

In response to ionizing radiation, stem cells enter a state of temporary quiescence, safeguarding the stem cell pool for tissue regeneration. Quiescence requires the inhibition of mTORC1, a kinase complex that promotes growth and suppresses autophagy, and cell cycle re-entry requires the reactivation of mTORC1. The pharmacological inhibition of mTORC1 in quiescent stem cells by rapamycin prevents cell cycle re-entry and subsequent tissue regeneration. It is well established that pharmacological responses can vary across genetic backgrounds, however, the extent to which genetic variation can impact the quiescence response to rapamycin is unclear. Here, we tested the sensitivity of stem cell quiescence to rapamycin in different genetic backgrounds within the

Identifiers

PMID41573946
PMCPMC12822713

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.