Evidence map›Paper›PMID 41573937›Full record

ArticlebioRxiv : the preprint server for biology2025

Lifespan-extending downregulation of insulin signalling reduces germline mutation load.

Elizabeth M L Duxbury, Alice M Godden, Jean-Charles de Coriolis, Hanne Carlsson, Simone Immler, Alexei A Maklakov

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elizabeth M L DuxburySchool of Biological Sciences, University of East Anglia, Norwich, United Kingdom.ORCID 0000-0002-5733-3645
Alice M GoddenSchool of Biological Sciences, University of East Anglia, Norwich, United Kingdom.ORCID 0000-0001-5760-011X
Jean-Charles de CoriolisSchool of Biological Sciences, University of East Anglia, Norwich, United Kingdom.ORCID 0009-0003-9068-3297
Hanne CarlssonSchool of Biological Sciences, University of East Anglia, Norwich, United Kingdom.ORCID 0000-0002-3001-8258
Simone ImmlerSchool of Biological Sciences, University of East Anglia, Norwich, United Kingdom.ORCID 0000-0003-1234-935X
Alexei A MaklakovSchool of Biological Sciences, University of East Anglia, Norwich, United Kingdom.ORCID 0000-0002-5809-1203

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Reduced insulin/IGF-1 signalling (IIS) robustly extends lifespan and enhances somatic stress resistance across taxa, yet its consequences for germline genome integrity remain unclear. Here we combine multigenerational mutation accumulation with whole-genome sequencing in

Indexed as

ageinggermline mutation loadinsulin signallingtrade-offs

Identifiers

PMID41573937
PMCPMC12822730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.