Evidence map›Paper›PMID 41573925›Full record

ArticlebioRxiv : the preprint server for biology2026

A developmentally regulated long-range enhancer-promoter contact mediates human neural development.

Devin Bready, Shuai Wang, Niklas Ravn-Boess, Joshua Frenster, Jonathan Sabio, Robert Kushmakov, Finnegan Clark, Adler Guerrero, Cathryn Lapierre, Kristyn Galbraith and 11 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Devin BreadyDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.
Shuai WangDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.
Niklas Ravn-BoessDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.
Joshua FrensterDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.ORCID 0000-0003-2401-1575
Jonathan SabioDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.
Robert KushmakovDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.
Finnegan ClarkInstitute for Systems Genetics, New York University Grossman School of Medicine, NY.
Adler GuerreroDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.
Cathryn LapierreDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.
Kristyn GalbraithDepartment of Pathology, New York University Grossman School of Medicine, NY.
Catherine DoDepartment of Pathology, New York University Grossman School of Medicine, NY.
Priscillia LhoumaudDepartment of Pathology, New York University Grossman School of Medicine, NY.
Jod PradoDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.
Albert JiangDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.
Sara HaddockDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.
Claire D KimDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.
Matija SnuderlDepartment of Pathology, New York University Grossman School of Medicine, NY.ORCID 0000-0003-0752-0917
Timothée LionnetInstitute for Systems Genetics, New York University Grossman School of Medicine, NY.
Aristotelis TsirigosDepartment of Pathology, New York University Grossman School of Medicine, NY.ORCID 0000-0002-7512-8477
Jane SkokDepartment of Pathology, New York University Grossman School of Medicine, NY.
Dimitris G PlacantonakisDepartment of Neurosurgery, New York University Grossman School of Medicine, NY.

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
The impact of changes in chromatin architecture on cancer phenotypes and tumor progressionP01CA229086 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Iannis Aifantis · 2019 to 2026
$17.0M
Nuclear organization and its role in gene regulationR35GM122515 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jane Amanda Skok · 2017 to 2026
$7.1M
Dissecting CEBPB Function with Synthetic Biology and ImagingR01AG075272 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Timothee Lionnet · 2022 to 2026
$3.2M
Developmentally Regulated Enhancers and Chromatin Architecture in Human NeurogenesisR01NS124920 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dimitris G. Placantonakis · 2022 to 2026
$2.7M
The role of GPR133 in glioblastomaR01NS102665 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PLACANTONAKIS, DIMITRIS G. · 2018 to 2022
$2.3M
Remodeling of 3D chromatin in B cell acute leukemia and its impact on clinical outcomeR01CA260028 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CARROLL, WILLIAM L., LIONNET, TIMOTHEE · 2021 to 2025
$2.2M
Calcium dynamics and signaling in gliomaR21NS126806 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PLACANTONAKIS, DIMITRIS G. · 2022 to 2022
$466k
Chromatin Organization in Glioma InitiationF30CA247418 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREADY, DEVIN MICHAEL · 2021 to 2023
$142k
NCI NIH HHS F30 CA247418NCI NIH HHS P01 CA229086NCI NIH HHS P30 CA016087NCI NIH HHS R01 CA260028NIA NIH HHS R01 AG075272NIGMS NIH HHS R35 GM122515NINDS NIH HHS R01 NS102665NINDS NIH HHS R01 NS124920NINDS NIH HHS R21 NS126806
6 · The paper itself

Abstract

SOX2 is a core pluripotency factor in human embryonic stem cells (hESCs), but upon differentiation to the three germ layers, its expression is preserved selectively in neuroectoderm. The mechanisms regulating

Indexed as

chromatin organizationCTCFdevelopmentenhancerforebraingene regulationneuroectodermSOX2

Identifiers

PMID41573925
PMCPMC12822576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.