ArticlebioRxiv : the preprint server for biology2025
RhlR quorum-sensing receptor ligand sensitivity regulates the differential expression of phenazine genes in
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Bacteria control individualistic and group behaviors using a form of cell-cell communication called quorum sensing. Quorum sensing relies on the production of chemical signals called autoinducers and the subsequent detection of those signals by a cognate receptor. Many Gram-negative bacteria use the LuxR-type family of transcription factor receptors that bind to acyl-homoserine lactone autoinducer signals to regulate their function as DNA-binding proteins. A subclass of this family of transcription factor receptors requires their cognate autoinducer to fold and dimerize to bind DNA to regulate gene expression and, thus, traits associated with quorum sensing, such as biofilm formation and virulence factor production. Here, we use a chemical-genetic approach to determine the structural basis for ligand selection by the quorum-sensing receptor RhlR from
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