Evidence map›Paper›PMID 41573872›Full record

ArticlebioRxiv : the preprint server for biology2025

Dietary Indoles Modulate Gut Barrier Integrity via the AhR-IL-22 Axis in ART-Treated SIV Infection.

Siva Thirugnanam, Alison R Van Zandt, Alexandra B McNally, Victoria A Hart, Isabelle Berthelot, Lara A Doyle-Meyers, David A Welsh, Andrew G MacLean, Namita Rout

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Siva ThirugnanamTulane National Primate Research Center; Covington, LA, USA.
Alison R Van ZandtTulane National Primate Research Center; Covington, LA, USA.
Alexandra B McNallyTulane National Primate Research Center; Covington, LA, USA.
Victoria A HartTulane National Primate Research Center; Covington, LA, USA.
Isabelle BerthelotTulane National Primate Research Center; Covington, LA, USA.
Lara A Doyle-MeyersTulane National Primate Research Center; Covington, LA, USA.
David A WelshDepartment of Microbiology, Immunology and Parasitology, Louisiana State University School of Medicine, New Orleans, LA, USA.
Andrew G MacLeanTulane National Primate Research Center; Covington, LA, USA.ORCID 0000-0002-0356-0674
Namita RoutTulane National Primate Research Center; Covington, LA, USA.

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
The role of the CMV-associated reactive oxygen species in age-relatedP20GM103629 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI TIAN, AIGUO · 2012 to 2021
$22.4M
Gamma Delta T cell and microbial modulation to target chronic SIV-associated inflammationR01DK131930 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI Namita Rout · 2022 to 2026
$3.6M
High Throughput Multicolor Flow Cytometer Cell AnalyzerS10OD026800 · OD · TULANE UNIVERSITY OF LOUISIANA · PI KAUR, AMITINDER · 2019 to 2019
$594k
Innate immune mechanisms of epithelial barrier disruption during treated HIV and SIV infectionsR56DK131531 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI ROUT, NAMITA, WELSH, DAVID A · 2022 to 2022
$555k
NIDDK NIH HHS R01 DK131930NIDDK NIH HHS R56 DK131531NIGMS NIH HHS P20 GM103629NIH HHS P51 OD011104NIH HHS S10 OD026800
6 · The paper itself

Abstract

HIV infection rapidly impairs the gastrointestinal (GI) barrier, contributing to persistent mucosal immune dysfunction, microbial translocation, and systemic inflammation despite antiretroviral therapy (ART). Using SIV-infected rhesus macaques on long-term ART, we investigated mechanisms underlying impairment in gut barrier-protective IL-17/IL-22 responses and the potential modulation of this pathway by dietary indoles. Longitudinal profiling of colonic epithelial and lamina propria cells revealed a selective loss of IL-17/IL-22-producing γδ T cells and type 3 innate lymphoid cells (ILC3s). This loss correlated with reduced expression of the transcription factors AhR and RORγt and was associated with elevated plasma markers of intestinal epithelial barrier disruption (IEBD), including intestinal fatty acid-binding protein (iFABP), zonulin, and LPS-binding protein (LBP). Targeting this transcriptional deficiency, dietary indole supplementation for one month restored colonic AhR

Indexed as

AhRHIVIEBDiFABPIL-17IL-22ILC3indoleRORγtγδ T

Identifiers

PMID41573872
PMCPMC12822695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.