ArticlebioRxiv : the preprint server for biology2025
Activation of the Spx redox sensor counters cysteine-driven Fe(II) depletion under disulfide stress.
Abigail G Hall, Abdulelah A Alqarzaee, Aliyah J Collins, Sasmita Panda, Svetlana Romanova, Sujata S Chaudhari, Andrew J Monteith, Dorte Frees, Vinai C Thomas
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In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Abigail G HallCenter for Staphylococcal Research, Department of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5900, USA.
Abdulelah A AlqarzaeeCenter for Staphylococcal Research, Department of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5900, USA.
Aliyah J CollinsDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Sasmita PandaCenter for Staphylococcal Research, Department of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5900, USA.
Svetlana RomanovaDepartment of Pharmaceutical Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska 68198-5900, USA.
Sujata S ChaudhariCenter for Staphylococcal Research, Department of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5900, USA.ORCID 0000-0002-9609-152X Andrew J MonteithDepartment of Microbiology, University of Tennessee, Knoxville, TN, USA.
Dorte FreesDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1870, Frederiksberg C, Denmark.ORCID 0000-0003-4946-2890 Vinai C ThomasCenter for Staphylococcal Research, Department of Pathology, Microbiology and Immunology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5900, USA.ORCID 0000-0002-7886-0727 Funding
The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2009 to 2023
$32.1MThe role of arginine catabolic pathways in modulating staphylococcal fitnessR01AI125588 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI THOMAS, VINAI · 2018 to 2022
$1.9MDefining the mitochondrial metabolic regulation of systemic innate inflammationR35GM154838 · NIGMS · UNIVERSITY OF TENNESSEE KNOXVILLE · PI Andrew J Monteith · 2024 to 2026
$1.1MNIAID NIH HHS P01 AI083211NIAID NIH HHS R01 AI125588NIGMS NIH HHS R35 GM154838
6 · The paper itselfAbstract
In many low G+C Gram-positive bacteria, the global regulator Spx helps maintain thiol homeostasis during disulfide stress, when protein thiols form aberrant disulfide bonds that can lead to misfolding and oxidative damage. Spx-dependent gene expression is triggered when an intramolecular disulfide bond forms between two cysteines in its redox switch. Surprisingly, some Spx functions persist even in the absence of an active redox switch, highlighting the need to better understand the physiological significance of maintaining this regulatory feature. Here, we utilize a
Indexed as
cysteinedisulfide stressironoxidative stressSpxStaphylococcus aureus
Identifiers
PMID41573845
PMCPMC12822559
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