ArticlebioRxiv : the preprint server for biology2025
Differential targeting of human pyroptotic Caspase-5 and Caspase-4 by
Kyungsub Kim, Marcos Antonio Valdespino Diaz, Rowan Karr, Michele E Muscolo, Lisa Goers, Truelian Yu, Tera C Levin, Jonathan N Pruneda, Cammie F Lesser
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Kyungsub KimDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA.ORCID 0000-0003-2897-0220 Marcos Antonio Valdespino DiazDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA.
Rowan KarrDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA.
Michele E MuscoloDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA.ORCID 0009-0004-7653-0785 Lisa GoersDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA.
Truelian YuDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA.
Jonathan N PrunedaDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR.
Cammie F LesserDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA.ORCID 0000-0002-1702-6333 Funding
INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1MShigella mediated regulation of epithelial cell inflammasomesR01AI169795 · NIAID · TUFTS UNIVERSITY BOSTON · PI CAMMIE LESSER · 2023 to 2026
$3.0MExploiting bacterial effector proteins to study human ubiquitin signalingR35GM142486 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Jonathan N Pruneda · 2021 to 2026
$2.6MTIR domains and the ancestry of innate immunityR35GM150681 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tera Catherine Levin · 2023 to 2026
$1.6MNIAID NIH HHS R01 AI169795NIAID NIH HHS T32 AI007061NIGMS NIH HHS R35 GM142486NIGMS NIH HHS R35 GM150681
6 · The paper itselfAbstract
Pyroptosis is an inflammatory cell death pathway that is a key defense mechanism of intestinal epithelial cells. To successfully establish an infection, intracytosolic Gram-negative pathogens must block this host response. Indeed,
Identifiers
PMID41573832
PMCPMC12822615
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