ArticlebioRxiv : the preprint server for biology2025
Harmine Selectively Drives Human Beta Cell Differentiation and Function Via Protein Kinase A Pathways.
Peng Wang, Kunal Kumar, Luca Lambertini, Hongtao Liu, Olivia Wood, Shuxuan Chen, Aidan Pillard, Donald K Scott, Joao A Paulo, Steven P Gygi and 7 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
17 authors.
Kunal KumarThe Department of Pharmacological Sciences.
Luca LambertiniThe Diabetes Obesity Metabolism Institute.
Hongtao LiuThe Diabetes Obesity Metabolism Institute.
Olivia WoodThe Diabetes Obesity Metabolism Institute.
Shuxuan ChenThe Diabetes Obesity Metabolism Institute.
Aidan PillardThe Diabetes Obesity Metabolism Institute.
Donald K ScottThe Diabetes Obesity Metabolism Institute.
Joao A PauloHarvand Medical School, Cambridge MA.
Steven P GygiHarvand Medical School, Cambridge MA.
Susmita KhamruiThe Department of Pharmacological Sciences.
Stefan MuellerEvotec GmbH, Munich, Germany.
Adolfo Garcia-OcanaThe Arthur Riggs Diabetes and Metabolism Research Institute, City of Hope, Duarte, CA.
Esra KarakoseThe Diabetes Obesity Metabolism Institute.
Michael B LazarusThe Department of Pharmacological Sciences.
Robert DeVitaThe Department of Pharmacological Sciences.
Andrew F StewartThe Diabetes Obesity Metabolism Institute.
Funding
Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI STREAMSON C CHUA · 2015 to 2026
$27.7MPROJECT 4: Interrogating PP2A Signaling in Human CancersP01CA203655 · NCI · DANA-FARBER CANCER INST · PI DECAPRIO, JAMES A. · 2017 to 2021
$8.0MThe DREAM B-Myb-MuvB complex controls sensitivity to DNA replication activators and inhibitorsR35CA232128 · NCI · DANA-FARBER CANCER INST · PI DECAPRIO, JAMES A. · 2019 to 2025
$7.2MChemical and structural tools to study energy homeostasis pathways in cancer and diabetesR35GM124838 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Michael Block Lazarus · 2017 to 2026
$5.2MDYRK Inhibitors for Human Beta Cell ExpansionR01DK105015 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DEVITA, ROBERT J, GARCIA-OCANA, ADOLFO · 2016 to 2024
$4.9MNovel Selective Type II kinase Inhibitors to treat DiabetesR01DK116904 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DEVITA, ROBERT J, STEWART, ANDREW F. · 2018 to 2022
$3.8MEpigenetic Control of Human Beta Cell ProliferationR01DK116873 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARGMANN, CARMEN, SCOTT, DONALD K. · 2018 to 2022
$3.2MDREAM Complex Maintenance of Human Beta Cell QuiescenceR01DK129196 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI STEWART, ANDREW F., WANG, PENG · 2021 to 2025
$3.0MBiological and Medicinal Chemistry Approaches to Human Beta Cell RegenerationR01DK125285 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DEVITA, ROBERT J, GARCIA-OCANA, ADOLFO · 2020 to 2023
$2.5MNrf2 and the expansion and preservation of beta cell massR01DK139631 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Maureen A Gannon, Adolfo Garcia-Ocana · 2024 to 2026
$2.2MAdvancing Multiplexed Isobaric Tag-based Strategies for Proteome ProfilingR01GM132129 · NIGMS · HARVARD MEDICAL SCHOOL · PI PAULO, JOAO A · 2019 to 2023
$1.7MNCI NIH HHS P01 CA203655NCI NIH HHS R35 CA232128NIDDK NIH HHS P30 DK020541NIDDK NIH HHS R01 DK105015NIDDK NIH HHS R01 DK116873NIDDK NIH HHS R01 DK116904NIDDK NIH HHS R01 DK125285NIDDK NIH HHS R01 DK129196NIDDK NIH HHS R01 DK139631NIGMS NIH HHS R01 GM132129NIGMS NIH HHS R35 GM124838
6 · The paper itselfAbstract
Harmine and other small molecule inhibitors of the kinase DYRK1A induce human beta cells to replicate and regenerate
Identifiers
PMID41573826
PMCPMC12822811
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