Evidence map›Paper›PMID 41573818›Full record

ArticlebioRxiv : the preprint server for biology2025

The long noncoding RNA

Jade Enright Hostetler, Fion Shiau, Xiaodong Zhang, Shiming Chen, Philip A Ruzycki, Seth Blackshaw, Brian S Clark

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Jade Enright HostetlerJohn F Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, 63110.ORCID 0000-0002-5051-2288
Fion ShiauJohn F Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, 63110.ORCID 0000-0003-0848-6562
Xiaodong ZhangJohn F Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, 63110.
Shiming ChenJohn F Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, 63110.ORCID 0000-0002-9299-5767
Philip A RuzyckiJohn F Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, 63110.ORCID 0000-0003-3520-6407
Seth BlackshawDepartments of Ophthalmology, Neuroscience, and Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.ORCID 0000-0002-1338-8476
Brian S ClarkJohn F Hardesty, MD Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, 63110.ORCID 0000-0002-7291-2055

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
WASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Philip Andrew Ruzycki · 1985 to 2026
$18.4M
Research Training Program in the Vision SciencesT32EY013360 · NEI · WASHINGTON UNIVERSITY · PI SHIMING CHEN, Daniel Kerschensteiner · 2000 to 2026
$5.6M
Transcriptional regulation of retinal cell differentiation and functionR01EY020560 · NEI · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2011 to 2021
$4.4M
Regulation of Retinal Development by RNA moleculesR01EY035381 · NEI · WASHINGTON UNIVERSITY · PI Brian S Clark · 2024 to 2026
$1.4M
Identification of the molecular mechanisms mediating intrinsic control of retinal progenitor competenceR00EY027844 · NEI · WASHINGTON UNIVERSITY · PI CLARK, BRIAN S · 2019 to 2021
$739k
Mapping the genomic landscape of developmental competence in retinaR21EY023448 · NEI · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2013 to 2014
$441k
Regulation of Retinal Progenitor Cell Competence by Long noncoding RNAsF32EY024201 · NEI · JOHNS HOPKINS UNIVERSITY · PI CLARK, BRIAN S · 2014 to 2016
$164k
NCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NEI NIH HHS F32 EY024201NEI NIH HHS P30 EY002687NEI NIH HHS R00 EY027844NEI NIH HHS R01 EY020560NEI NIH HHS R01 EY035381NEI NIH HHS R21 EY023448NEI NIH HHS T32 EY013360
6 · The paper itself

Abstract

Long noncoding RNAs (lncRNAs) display pervasive expression and function in the developing nervous system. Temporal profiling of gene expression in the retina has demonstrated differential expression of lncRNAs throughout development; however, determinations of lncRNA function during retinal development remain limited. In this study, we identify numerous lncRNAs with dynamic temporal expression and characterize the function of the lncRNA

Indexed as

Long noncoding RNAPeanutPhotoreceptor differentiationRetina developmentRetinal progenitor cells

Identifiers

PMID41573818
PMCPMC12822574

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.