Long-term relapse: markers, mechanisms, and implications for disease management in alcohol use disorder.

Objective: Much has been theorized and documented about factors involved in alcohol use disorder (AUD) relapse during the early months following a recovery attempt where biobehavioral classical conditioning ("cues/triggers") and neurophysiological explanatory theories predominate. Little has been documented, however, about long-term relapse (LTR) factors following sustained AUD remission where self-regulation and stress and coping theories may predominate because LTR precursors are centered less around neurophysiological dysregulation and cue reactivity and more around factors such as lowered recovery vigilance, avoidant coping, or changes in recovery-support services (RSS) usage. Greater knowledge of factors involved in LTR could sensitize and empower clinicians to deliver more effective disease management protocols to monitor and intervene upon such risks Methods: Cross-sectional, retrospective study of individuals in recovery from primary AUD ( Results: Several bio-psycho-social and RSS changes occurred during the year preceding LTR varying in prevalence and potency. Some were prevalent, but not potent, in terms of definitely contributing to LTR (e.g., sleep, energy); others occurred infrequently, but were potent (e.g., physical pain, recreational drug use); others were both highly prevalent and highly potent (e.g., change in recovery vigilance). Within participants, median number of definitely contributing LTR factors = 4, covering 2 different domains, on average. Temporal accumulation of LTR risks tended to intensify toward the relapse horizon over the preceding year. The single most important relapse factor tended to cluster in psychological (e.g., recovery vigilance, mental health) and social domains. Conclusions: Findings have implications for long-term disease management during AUD recovery providing a set of potential preliminary markers and mechanisms that might be assessed, monitored, and, when necessary, intervened upon prior to the onset of heavy symptomatic alcohol use to prevent AUD recurrence.