Evidence map›Paper›PMID 41573764›Full record

ArticleMultiple sclerosis journal - experimental, translational and clinical

Leptomeningeal enhancement in multiple sclerosis demonstrates posterior predilection and T

Ashley A Thommana, Erin S Beck, Matthew A Greenwald, Gina Norato, Hallie Gaitsch, Dzung L Pham, Steven Jacobson, María I Gaitán, Govind Nair, Daniel S Reich and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis journal - experimental, translational and clinical. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ashley A ThommanaNeuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID https://orcid.org/0009-0004-1117-8987
Erin S BeckNeuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID https://orcid.org/0000-0001-7839-7958
Matthew A GreenwaldNeuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID https://orcid.org/0009-0002-3366-5079
Gina NoratoClinical Trials Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-1324-0217
Hallie GaitschNeuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-6656-607X
Dzung L PhamDepartment of Radiology and Radiological Sciences, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-0053-2034
Steven JacobsonNeuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-3127-1287
María I GaitánNeuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-4455-5641
Govind NairNeuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-3725-615X
Daniel S ReichNeuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-2628-4334
Serhat V OkarNeuroimmunology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-3716-2196

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Leptomeningeal enhancement (LME) is a putative magnetic resonance imaging (MRI) marker of meningeal inflammation in multiple sclerosis (MS). 3D inversion-prepared fast-spin-echo sequence with real-reconstruction inversion recovery (Real-IR) MRI at 3 tesla (T) is highly sensitive to LME. Objectives: To assess LME prevalence across brain regions and characterize the relationship between LME and subtle cortical pathology. Methods: LME distribution patterns across brain regions were recorded for 90 adults (Age: 51 ± 11; women: 57; MS: 78) using 3T Real-IR. A subset of 15 participants had corresponding T Results: 243 LME foci were found across 65 participants (73%). One hundred and sixty-one (66.3%) LME foci were posterior to the central sulcus. Three of 15 7T participants had a cortical lesion nearby LME (3/49 foci). Mean T Conclusions: Regional variations in LME distribution may point to topographical differences in the blood-meningeal barrier. Alterations in T

Indexed as

blood-cerebrospinal fluid barrierleptomeningeal enhancementMRIMultiple sclerosisreal inversion-recovery MRI

Identifiers

PMID41573764
PMCPMC12820026

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.