Evidence map›Paper›PMID 41573746›Full record

ArticleFrontiers in molecular biosciences2025

Hypoxia-induced immunosuppression in uveal melanoma is mediated by CD63

Lei Dong, Suilian Zheng, Yixia Feng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lei DongDepartment of Ophthalmology, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang, China.
Suilian ZhengDepartment of Ophthalmology, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yixia FengDepartment of Ophthalmology, The Third Affiliated Hospital of Wenzhou Medical University, Ruian, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uveal melanoma (UM) is characterized by profound immunosuppression, resistance to immunotherapy, and significant hypoxia. This study investigates the role of hypoxia in mediating metabolic crosstalk with immune cells via CD63-enriched exosomes. Single-cell transcriptomic analysis identified a CD63-high tumor subpopulation in UM associated with lactate metabolism and vesicle transport. Under hypoxic conditions (1% O

Indexed as

exosomeshypoxiaimmunosuppressionlactateuveal melanoma

Identifiers

PMID41573746
PMCPMC12819323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.