ArticleFrontiers in oncology2025
Kinetic and radiomic features on DCE-MRI as a predictor for axillary lymph node metastasis burden in T1 and T2 stage breast cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Exploiting machine-learning models with DCE-MRI radiomics for breast cancer molecular subtyping.Frontiers in oncology · 2026Article
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9 authors.
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Abstract
Background: Magnetic resonance imaging (MRI) is increasingly used to evaluate axillary lymph node (ALN) status in breast cancer. However, the correlation between MRI features of the primary tumor and the ALN metastasis (ALNM) burden remains poorly understood. This study aimed to develop a non-invasive MRI-based model to preoperatively distinguish between low (≤2 nodes) and high (>2 nodes) ALNM burden in T1 and T2 stage breast cancer. Methods: This retrospective single-center study included 185 patients, categorized by ALNM burden [≤ 2 nodes (n = 149) or >2 nodes (n = 36)]. The kinetic and radiomic features were extracted from the segmented whole tumor on dynamic contrast-enhanced MRI (DCE-MRI). A forward-stepwise feature selection method was employed based on the ANOVA F-score from the training cohort. Features were added according to F-values and logistical regression model was built iteratively. The final model, trained on the entire training set, was evaluated on the independent test cohort. Results: The model incorporated five kinetic and three radiomic features, demonstrating moderate predictive performance. The model achieved an area under the receiver operating characteristic curve (AUC) of 0.705 in the test cohort. It showed a sensitivity of 72.7% and a specificity of 77.8%. The negative predictive value (NPV) was 92.1%. Conclusion: The kinetic and radiomic features from DCE-MRI showed potential for predicting ALNM burden (≤2 or > 2 nodes) in T1 and T2 stage breast cancer. The high NPV particularly supported their utility as a non-invasive tool to identify candidates for less invasive axillary procedures.
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