Evidence map›Paper›PMID 41573648›Full record

ArticleFrontiers in oncology2025

Treatment challenges in glioblastoma: a case report.

Domingos Roda, Filipa Oliveira, Pedro Veiga, Leonor Santos, Pedro Abreu, Ana Nascimento, Francisco Caramelo, Joana Barbosa Melo, Isabel Marques Carreira, Ilda Patrícia Ribeiro

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Domingos Roda *Algarve Radiation Oncology Unit, Joaquim Chaves Saúde (JCS), Faro, Portugal.
Filipa Oliveira *Cytogenetics and Genomics Laboratory, Institute of Cellular and Molecular Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Pedro VeigaCytogenetics and Genomics Laboratory, Institute of Cellular and Molecular Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Leonor SantosRadiation Oncology Service, Unidade Local de Saúde de Coimbra, Coimbra, Portugal.
Pedro AbreuNeurosurgery Service, Unidade Local de Saúde do Algarve, Algarve, Portugal.
Ana NascimentoNeurosurgery Service, Unidade Local de Saúde do Algarve, Algarve, Portugal.
Francisco CarameloLaboratory of Biostatistics and Medical Informatics, Instituto Biomédico de Investigação em Luz e Imagem (IBILI) - Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Joana Barbosa MeloCytogenetics and Genomics Laboratory, Institute of Cellular and Molecular Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Isabel Marques CarreiraCytogenetics and Genomics Laboratory, Institute of Cellular and Molecular Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Ilda Patrícia RibeiroCytogenetics and Genomics Laboratory, Institute of Cellular and Molecular Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This clinical case report aimed to show the survival timeline of a glioblastoma patient who underwent surgery and received adjuvant treatments in accordance with the Stupp protocol. Starting on the day of surgery, a liquid biopsy was employed to assess the dynamic alterations in cell-free DNA (cfDNA). Upon recurrence, reoperation was conducted, and repeated radiochemotherapy was applied. This clinical case is interesting due to the extended survival time, despite the extremely aggressive nature of the medical interventions. Liquid biopsies constitute a non-invasive method of characterising circulating tumour DNA (ctDNA) and evaluating genetic and epigenetic modifications, providing considerable potential for tumour diagnosis, prognosis, and management.

Indexed as

circulating tumour DNAcopy number alterationsgenetic and epigenetic signatureglioblastomaliquid biopsies

Identifiers

PMID41573648
PMCPMC12819219

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.