Evidence map›Paper›PMID 41573641›Full record

ArticleFrontiers in oncology2025

Nicholas E Bambach, Julio C Ricarte-Filho, Erin R Reichenberger, Christian Hernandez-Padilla, Kyle Hinkle, Amber Isaza, Andrew J Bauer, Aime T Franco

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

  • Update of
    2025
5 · Who and what money

Authors and funding

8 authors.

Nicholas E BambachDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Julio C Ricarte-FilhoDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Erin R ReichenbergerDepartment of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Christian Hernandez-PadillaDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Kyle HinkleDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Amber IsazaDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Andrew J BauerDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Aime T FrancoDivision of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, United States.

Funding

RESEARCH AND MENTORING EXCELLENCE IN DIVERSE AND INCLUSIVE ENVIRONMENTR01CA214511 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI FRANCO, AIME T. · 2018 to 2023
$2.7M
NCI NIH HHS R01 CA214511
6 · The paper itself

Abstract

The KEAP1/NRF2 pathway, a major regulator of the cellular oxidative stress response, is frequently activated in human cancers. Often mediated by loss-of-function mutations in

Indexed as

chr19pKEAP1LOHmutationNRF2pediatricselpercatinibthyroid cancer

Identifiers

PMID41573641
PMCPMC12819188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.