ArticleFrontiers in oncology2025
Prognostic value of tumour-associated neutrophils in different polarization status releasing neutrophil extracellular traps in the immunotherapy of advanced non-small cell lung cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The trial behind it
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Who cites it
5 citing papers in PubMed.
- Neutrophil Extracellular Traps in the Tumor Microenvironment: Mechanisms, Immune Regulation, and Implications for Immune Checkpoint Inhibitor Therapy.International journal of molecular sciences · 2026Review
- Human Group IIA Secreted Phospholipase AInternational journal of molecular sciences · 2026Review
- Review
- The Neutrophil-NET Axis in Immune Checkpoint Inhibitor Resistance in Non-Small Cell Lung Cancer: Roles, Biomarkers and Therapeutic Opportunities.Biomolecules · 2026Review
- Tumor immune microenvironment in non-small cell lung cancer progression.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study analyzed the polarization types of tumour-associated neutrophils (TANs) that release neutrophil extracellular traps (NETs), as well as the impact of neutrophil polarization on the efficacy of immunotherapy for non-small cell lung cancer (NSCLC). Methods: This study retrospectively collected clinical data and pathological samples of 115 patients with advanced NSCLC who underwent first-line immunotherapy. Multiplex immunofluorescence staining was used to assess TANs polarization status and NETs expression. Results: We found that the presence of NETs was negatively associated with tumour-associated N1 neutrophil ( Conclusion: Tumour-associated N2 neutrophils in NSCLC tissues are the primary cells releasing NETs, and tumour-associated N2 neutrophils with high NETs expression are associated with an immunosuppressive tumour microenvironment, which will impact the efficacy of first-line immunotherapy in NSCLC patients.
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Registered trials
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