ArticleFrontiers in immunology2025
Clinical characteristics and prognosis of paraneoplastic syndromes: a single-center cohort study in Northern China.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Article
- RNA-binding proteins: a comprehensive review of multifaceted regulatory mechanisms in neuroinflammation and implications in the pathogenesis of neurological disorders.Journal of neuroinflammation · 2026Review
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6 authors.
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Abstract
Purpose: To explore the clinical features, treatment, and prognosis of paraneoplastic neurological syndromes (PNS). Methods: In this retrospective cohort study, the records of 114 patients diagnosed with probable (n = 65) or definite (n = 49) PNS between July 2016 and October 2024 were analyzed. Short-term outcome was defined as the point decrease in modified Rankin Scale score from peak disease to discharge(Δmodified Rankin Scale). Long-term prognosis was determined by mortality at last follow-up. Prognostic factors were identified using logistic regression and Cox models. The impact of tumors and high-risk antibodies on survival were assessed by Kaplan-Meier curves. Results: Of the 114 patients, 65 (57.0%) were males. The median age was 63 years. Muscle weakness (53.5%) was most common, followed by seizures and altered consciousness. Associated tumors occurred in 66.7% of patients, mainly lung (65.8%) and breast cancer (9.2%). Antibodies were detected in 79.8%, including (single and multiple antibody types) anti-GABA Conclusions: Age < 65 years, CNS involvement and immunotherapy are relevant to favorable short-term outcome. SCLC and high-risk antibodies are adverse factors of long-term survival in PNS.
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