Evidence map›Paper›PMID 41573568›Full record

ArticleFrontiers in immunology2025

Long-term memory in epithelia: transient IFNγ exposure drives stable repression of TFF1 in gastric epithelial cells via epigenetic changes.

Antonia Voli, Daniela Eletto, Fatima Maria Mentucci, Chiara Centrella, Martina Pannetta, Francesco Boccellato, Alfonso Finizio, Silvana Morello, Caterina Giraulo, Amalia Porta and 1 more

Abstract read
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In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Antonia VoliDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Daniela ElettoDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Fatima Maria MentucciDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Chiara CentrellaDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Martina PannettaDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Francesco BoccellatoLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Alfonso FinizioCentro Trasfusionale, Ospedale S. Maria della Speranza, Battipaglia, Italy.
Silvana MorelloDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Caterina GirauloDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Amalia PortaDepartment of Pharmacy, University of Salerno, Fisciano, Italy.
Alessandra ToscoDepartment of Pharmacy, University of Salerno, Fisciano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Interferon-gamma (IFNγ) is a pro-inflammatory cytokine that is transiently produced and typically activates short-lived JAK-STAT1 signaling, yet it can also induce long-term transcriptional changes. During Methods: We exposed gastric epithelial cells to brief IFNγ stimulation and analyzed gene expression, transcription factor involvement, and epigenetic modifications. Chromatin remodeling at the TFF1 locus was assessed through histone modification analyses, and the role of DNA methylation was evaluated using pharmacological inhibitors. Findings were validated in primary gastric mucosoids exposed to inflammatory mediators released by Results: Transient IFNγ exposure caused stable repression of TFF1, a gastric tumor suppressor frequently lost in Discussion: Overall, our findings show that transient inflammatory signals cause durable gene silencing through epigenetic remodeling, revealing how chronic inflammation can reprogram epithelial cells and promote cancer, while suggesting strategies to reverse these effects.

Indexed as

Epigenesis, GeneticEpithelial CellsGastric MucosaInterferon-gammaTrefoil Factor-1Chromatin Assembly and DisassemblyDNA MethylationEpigenetic MemoryHelicobacter InfectionsHelicobacter pyloriHistonesHumansHistonesInterferon-gammaTFF1 protein, humanTrefoil Factor-1gastric mucosoidshelicobacterIFNγlong-term memoryTFF1

Identifiers

PMID41573568
PMCPMC12819787

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.