Evidence map›Paper›PMID 41573563›Full record

ReviewFrontiers in immunology2025

Glycan masking in immunogen design: computational and experimental methods.

Gustavo Araiza, Josuel Morel, Minh H Tran, Shan Jiang, Sean Murray, Emika Miyamoto, Hannah Vogts, Kyle L Brown, Jens Meiler, Cristina E Martina

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gustavo Araiza *Center for Structural Biology, Vanderbilt University, Nashville, TN, United States.
Josuel Morel *Center for Structural Biology, Vanderbilt University, Nashville, TN, United States.
Minh H TranCenter for Structural Biology, Vanderbilt University, Nashville, TN, United States.
Shan JiangCenter for Structural Biology, Vanderbilt University, Nashville, TN, United States.
Sean MurrayDepartment of Chemistry and Physics, Belmont University, Nashville, TN, United States.
Emika MiyamotoDepartment of Chemistry, Vanderbilt University, Nashville, TN, United States.
Hannah VogtsDepartment of Biomedical Engineering, University of Iowa City, Iowa, IA, United States.
Kyle L BrownCenter for Structural Biology, Vanderbilt University, Nashville, TN, United States.
Jens MeilerCenter for Structural Biology, Vanderbilt University, Nashville, TN, United States.
Cristina E MartinaCenter for Structural Biology, Vanderbilt University, Nashville, TN, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epitope-focused vaccine design aims to improve upon existing immunization strategies by eliciting immune responses against specific epitopes targeted by known therapeutic antibodies. One of the techniques in epitope-focused immunogen design is glycan masking, in which sugars are used to hide epitopes on the protein of interest that are associated with low therapeutic potency. Here, we provide a detailed overview of the computational and experimental techniques associated with glycan masking for immunogen design at a biochemical and biophysical level. We will cover well-established and emerging

Indexed as

EpitopesPolysaccharidesVaccinesAnimalsComputer SimulationGlycosylationHumansImmunoinformaticsProtein EngineeringEpitopesPolysaccharidesVaccinesepitope-focused vaccine designglycan maskingglycan shieldglycoengineeringimmunogen designN-linked glycosylationprotein-glycan modelingreverse vaccinology

Identifiers

PMID41573563
PMCPMC12819649

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.