Evidence map›Paper›PMID 41573550›Full record

ArticleFrontiers in immunology2025

Tuft cell cysteinyl leukotrienes are necessary for rhinovirus-induced mucus metaplasia, type 2 inflammation and airway hyperresponsiveness in immature mice.

De'Jana T Parker, J Kelley Bentley, Jing Lei, Baljeet Domala, Hannah L Briggs, Shilpi Singh, Yiran Li, M Claire Reiner, Derek A Flores, Alex L Sliwicki and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

De'Jana T ParkerDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
J Kelley BentleyDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Jing LeiDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Baljeet DomalaDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Hannah L BriggsDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Shilpi SinghDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Yiran LiDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
M Claire ReinerDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Derek A FloresDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Alex L SliwickiDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Heidi R FloriDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.
Marc B HershensonDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, United States.

Funding

Early Life Rhinovirus Infection and Childhood AsthmaR01AI120526 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERSHENSON, MARC B. · 2016 to 2024
$3.9M
Models of rhinovirus-C respiratory infection and asthmaR01AI155444 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERSHENSON, MARC B. · 2020 to 2024
$2.1M
NIAID NIH HHS R01 AI120526NIAID NIH HHS R01 AI155444
6 · The paper itself

Abstract

Introduction: Early-life wheezing-associated respiratory tract infections with rhinovirus (RV) are considered risk factors for asthma development. Cysteinyl leukotrienes (cysLTs) are pro-inflammatory lipid mediators synthesized from arachidonic acid by 5-lipoxygenase (Alox5) and Alox5 activating protein (Alox5ap). We hypothesized that tuft cell-derived cysLTs are required for the development of an asthma phenotype in immature mice undergoing heterotypic RV infection. Methods: We infected C57BL/6, Results: After heterologous RV infection, C57BL/6 mice showed increased lung cysLT levels and mRNA expression of Conclusions: Tuft cell-derived cysLTs are required for mucous metaplasia, type 2 inflammation and airways hyperresponsiveness in immature mice exposed to heterologous viral infection.

Indexed as

CysteineLeukotrienesPicornaviridae InfectionsRespiratory HypersensitivityRhinovirusTuft Cells5-Lipoxygenase-Activating ProteinsAnimalsArachidonate 5-LipoxygenaseDisease Models, AnimalFemaleHeLa CellsHumansInflammationMaleMetaplasia5-Lipoxygenase-Activating ProteinsAlox5ap protein, mouseArachidonate 5-LipoxygenaseCysteinecysteinyl-leukotrieneLeukotrienesasthmacysteinyl leukotrienerespiratory viralrhinovirustuft cells

Identifiers

PMID41573550
PMCPMC12819791

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.