Evidence map›Paper›PMID 41573534›Full record

ArticleFASEB bioAdvances2026

Increased Orexin by High Concentration of Sevoflurane Enhances the Suprahyoid Muscle Activity Involves in Gasping-Like Respiration of Mice.

Yoko Irukayama-Tomobe, Jun-Dal Kim, Hisayo Jin, Saki Taiji, Tsuyoshi Nemoto, Dai Horiuchi, Yunosuke Ogata, Tomoya Hamamura, Tomoko Misawa, Takashi Kanbayashi and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB bioAdvances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yoko Irukayama-TomobeMedical Mycology Research Center (MMRC) Chiba University Chiba Japan.
Jun-Dal KimDivision of Complex Biosystem Research, Department of Research and Development, Institute of Natural Medicine University of Toyama Toyama Japan.ORCID https://orcid.org/0000-0002-7361-0999
Hisayo JinDepartment of Anesthesiology, Graduate School of Medicine Chiba University Chiba Japan.
Saki TaijiDepartment of Anesthesiology, Graduate School of Medicine Chiba University Chiba Japan.
Tsuyoshi NemotoChiba University Hospital Chiba Japan.
Dai HoriuchiDepartment of Respirology, Graduate School of Medicine Chiba University Chiba Japan.
Yunosuke OgataChiba University School of Medicine Chiba Japan.
Tomoya HamamuraChiba University School of Medicine Chiba Japan.
Tomoko MisawaDepartment of Respirology, Graduate School of Medicine Chiba University Chiba Japan.
Takashi KanbayashiInternational Institute for Integrative Sleep Medicine (IIIS) University of Tsukuba Tsukuba Japan.
Takashi NishinoDepartment of Anesthesiology, Graduate School of Medicine Chiba University Chiba Japan.
Shiroh IsonoMedical Mycology Research Center (MMRC) Chiba University Chiba Japan.
Takuji SuzukiDepartment of Respirology, Graduate School of Medicine Chiba University Chiba Japan.
Yoshitoshi KasuyaDepartment of Respirology, Graduate School of Medicine Chiba University Chiba Japan.
Koichiro TatsumiMedical Mycology Research Center (MMRC) Chiba University Chiba Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gasping respiration enhances survival chances during cardiac arrest by activating the suprahyoid muscles (SHMs), which are crucial for airway dilation. We previously reported that the high concentration of sevoflurane (6.5%: 2.0 minimum alveolar concentration, MAC) leads to gasping-like respiration in mice. Here, to understand the molecular mechanisms of this phenomenon, we compared the hypothalamic transcriptome profiles among control, 2.3% sevoflurane (0.7 MAC; eupnea), and 2.0 MAC groups and identified the differentially expressed genes (DEGs), in which hypocretin (orexin) precursor (

Indexed as

gasping respirationhypothalamic transcriptomeorexinsevofluranesuprahyoid muscle

Identifiers

PMID41573534
PMCPMC12820793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.