Evidence map›Paper›PMID 41573513›Full record

ArticleFrontiers in cardiovascular medicine2025

Effects of fasting on endothelial function in type 2 diabetes mellitus patients: cohort study.

Feten Lamti, Salma Messous, Marwa Toumia, Imen Trabelsi, Randa Dhaoui, Khaoula Bel Haj Ali, Ekram Hajji, Bilal Benamor, Adel Sekma, Rahma Jaballah and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Feten LamtiResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Salma MessousResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Marwa ToumiaResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Imen TrabelsiResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Randa DhaouiResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Khaoula Bel Haj AliResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Ekram HajjiDepartment of Endocrinology and Internal Medicine, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Bilal BenamorDepartment of Endocrinology and Internal Medicine, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Adel SekmaResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Rahma JaballahEmergency Department, Sahloul University Hospital, Sousse, Tunisia.
Hajer YaakoubiEmergency Department, Sahloul University Hospital, Sousse, Tunisia.
Asma ZorgatiEmergency Department, Sahloul University Hospital, Sousse, Tunisia.
Kaouthar BeltaiefResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Houda Ben SoltaneEmergency Department, Farhat Hached University Hospital, Sousse, Tunisia.
Zied MezgarEmergency Department, Farhat Hached University Hospital, Sousse, Tunisia.
Mariem KhroufEmergency Department, Farhat Hached University Hospital, Sousse, Tunisia.
Imen Ben AbdallahLaboratory of Biochemistry and Toxxicology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Amira SghaierEmergency Department, Taher Sfar University Hospital, Mahdia, Tunisia.
Nahla JerbiEmergency Department, Taher Sfar University Hospital, Mahdia, Tunisia.
Rabie RazgallahDACIMAConsulting, Tunis, Tunisia.
Ilhem HallaraResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Wahid BouidaResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Mohamed Habib GrissaResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Jamel SaadDepartment of Imaging and Interventional Radiology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Hamdi BoubakerResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Riadh BoukefResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Fadoua NeffatiLaboratory of Biochemistry and Toxxicology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Nabil SaklyDepartement of Immunology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Zohra DridiDepartement of Cardiology, Fattouma Bourguiba University Hospital, Monastir, Tunisia.
Mohamed Amine MsolliResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Asma SrihaResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Ines KhochtaliResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.
Semir NouiraResearch Laboratory LR12SP18, Monastir University, Monastir, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The aim of this study was to investigate the effect of Ramadan fasting (RF) on markers of endothelial function and metabolic parameters in patients with type 2 diabetes mellitus (T2DM) and healthy controls. Methods: This cohort study involved 305 subjects: 167 T2DM and 138 healthy volunteers subjects. The following parameters were evaluated: body mass index (BMI), diet inflammatory index (DII), serum glucose and lipid profile and high-sensitivity C-reactive protein (hs-CRP) during three separate visits, before Ramadan (baseline), the last week of Ramadan, and during the last week of the month following Ramadan. In each visit, reactive hyperaemia index (RHI) in all participants was assessed. In diabetic patients, serum homocyteine (Hcys) was mesured at baseline and during RF. The primary endpoint was change in RHI, a validated and non-invasive measure of endothelial function. The secondary end point was change in clinical, metabolic parameters, and Hcys. Analyses used non-parametric tests and multivariable regression with multiple imputation. Results: RF significantly decreased RHI [-0.2 UI (95% CI -0.3 to -0.09); Conclusion: RF seems to be associated with unfavorable effects on endothelial function in diabetic patients but not in healthy subjects. RHI testing could help identifying diabetic patients who should not observe RF or should be closely monitored during fasting.

Indexed as

diabet mellitus type 2endothelial functionfasting (Ramadan)homocysteinereactive hyperaemia index

Identifiers

PMID41573513
PMCPMC12819813

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