ArticleFrontiers in cardiovascular medicine2025
Global research trends on exosomes in atherosclerosis: a bibliometric and scientometric analysis (2004-2025).
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Exosomes play multifaceted roles in atherosclerosis, contributing to vascular inflammation, immune regulation, and tissue repair. This duality has drawn attention to their potential clinical utility, both as diagnostic indicators and as novel therapeutic avenues. However, despite the rapid expansion of research, a comprehensive scientometric overview of this field remains lacking. Methods: From 2004 to July 29, 2025, publications related to exosomes and atherosclerosis were screened in the Web of Science Core Collection (WoSCC) and Scopus. After deduplication, 1,179 records (964 articles, 215 reviews) were included. Bibliometric analyses were conducted using CiteSpace, VOSviewer, and the bibliometrix R package. Indicators examined included publication trends, global distribution, institutional and author contributions, co-citation patterns, and keyword evolution. Results: Publications on exosomes in atherosclerosis have risen sharply since 2015, consistent with Price's Law. China contributes the largest volume, while the United States shows stronger international collaboration. Central South University, Capital Medical University, and Harvard University rank among the most productive institutions. Key contributors include Elena Aikawa and Lijun Yuan. Major publication venues are the International Journal of Molecular Sciences, Frontiers in Cardiovascular Medicine, and Frontiers in Immunology. Keyword and co-citation mapping revealed three major research axes: RNA-mediated regulation, immune and endothelial interactions, and emerging translational applications such as engineered exosomes and diagnostic biomarkers. Conclusion: This bibliometric analysis characterizes global research development and shows a shift from descriptive studies toward mechanistic insight and translational innovation. These trends may facilitate future efforts in biomarker discovery, standardized exosome workflows, and therapeutic development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.