ReviewCureus2025
A Literature Review of the Renal Manifestations in Pediatric Celiac Disease and Its Associated Clinical Implications.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Celiac disease (CeD) is a chronic autoimmune disorder predominantly targeting the small intestine, in which the immune system reacts to gluten. It is increasingly recognized as a systemic condition with potential renal involvement and is observed in children worldwide. There have been reports of renal manifestations in children with CeD across Europe, North Africa, the Middle East, and parts of Asia, including immunoglobulin A (IgA) nephropathy (IgAN), diabetic nephropathy, and urolithiasis. These conditions are frequently associated with immune complex deposition, persistent inflammation, and nutritional deficits caused by malabsorption. Despite increased recognition, research in pediatric populations remains limited, and screening and management practices are inconsistent. This study identifies renal impairment as an underrecognized extraintestinal manifestation of CeD in the pediatric population, emphasizing the protective role of an early gluten-free diet and summarizing current evidence on mechanisms and clinical presentation to guide future pediatric-focused research.
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Registered trials
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