ArticleCureus2025
A Case of Metastatic Renal Cell Carcinoma Developing Isolated Adrenocorticotropic Hormone (ACTH) Deficiency During Nivolumab Therapy.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
We report a case of isolated adrenocorticotropic hormone (ACTH) deficiency that developed after nivolumab therapy for metastatic renal cell carcinoma involving the pancreas and thyroid. The patient presented with nonspecific symptoms that improved promptly after discontinuation of nivolumab and initiation of hydrocortisone replacement therapy. Despite permanently requiring glucocorticoid supplementation, the patient has maintained a durable partial response for more than four years after cessation of nivolumab. This case highlights the importance of early recognition of immune-related endocrinopathies and demonstrates that long-term tumor control may be achieved even after discontinuation of immune checkpoint inhibitors.
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