ReviewCureus2025
Hypertension and Risk of Stroke: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite strong evidence linking hypertension (HTN) to stroke, updated syntheses are needed to refine risk estimates by stroke subtype and population group. This systematic review quantified HTN-associated stroke risk and examined variations across subtypes. Across 24 studies (n = 1.8 million), HTN increased overall stroke risk by approximately twofold (odds ratio (OR)/hazard ratio (HR)/risk ratio (RR): 1.3-2.1), with the strongest association observed for hemorrhagic stroke (OR = 2.1) and among Asian populations (RR = 2.0). Women had a higher risk (HR = 1.5) than men (HR = 1.3). Each 5-mmHg reduction in systolic blood pressure (SBP) lowered stroke risk by 22% (RR = 0.78), while intensive control (SBP < 120 mmHg) reduced incidence by 41% among people with diabetes. Post-stroke BP management (SBP < 140 mmHg) decreased recurrence by 35% (HR = 0.65). Considerable heterogeneity (I² = 93.2%) was attributed to variations in HTN definitions and population characteristics. Overall, HTN remains a potent and modifiable stroke risk factor, with differential effects by subtype and sex. Intensive and targeted BP control, particularly in high-risk groups, significantly reduces stroke burden. Standardized methods and tailored interventions are needed to address heterogeneity and optimize prevention strategies.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.