ArticleCureus2025
Solitary Cutaneous Nodule as the Initial Presentation of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is an indolent mature B-cell neoplasm that may rarely involve the skin, where it can clinically mimic primary cutaneous B-cell lymphomas (PCBCLs). When the skin is involved, lesions often appear as erythematous or violaceous papules, plaques, or nodules on the head, neck, or trunk. An 85-year-old male presented for evaluation of slowly enlarging, asymptomatic nodules on the right upper back and left posterior shoulder that had been present for many years. A shave biopsy of the right upper back lesion revealed a nodular dermal infiltrate of small lymphocytes. Immunohistochemistry showed CD20, CD79a, CD23, CD5, and BCL2 positivity with low Ki-67, consistent with CLL/SLL. A second-opinion review at the National Institutes of Health confirmed the diagnosis and identified low-level marrow involvement by CLL/SLL. Whole-body positron emission tomography (PET) showed no hypermetabolic lymphadenopathy or visceral disease. The patient underwent excision of the back nodule with complex primary closure, and follow-up examinations have shown a well-healed scar without local recurrence. This case illustrates how CLL/SLL can present with a solitary cutaneous nodule and underscores the importance of histopathology and immunophenotyping in distinguishing secondary cutaneous involvement by systemic lymphoma from PCBCLs, as management and prognosis differ.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.