ArticleFrontiers in bioengineering and biotechnology2025
Preliminary evaluation of full volume strain measurement in patellar cartilage following osteochondral allograft transplantation using magnetic resonance imaging.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Combined cartilage thickness and mechanical property mismatch drives local strain amplification at the patellar osteochondral allograft interface.Biomechanics and modeling in mechanobiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Articular cartilage (AC) defects of the patellofemoral joint (PFJ) are clinically challenging and mechanically demanding. Osteochondral allograft (OCA) transplantation is the standard treatment for large cartilage injuries; however, little is known about intra-tissue mechanics after transplantation. Computational models suggest that cartilage thickness mismatch concentrates stresses at donor-recipient interfaces in OCA-treated patella, but direct experimental evidence is scarce. Local cartilage strain is closely linked to tissue health; therefore, the goal of this work was to provide a preliminary, full volume assessment of patellar cartilage mechanics before and after OCA transplantation. Methods: A displacement-encoded MRI sequence was used to quantify full volume displacement and strain fields in human patellar AC before and after OCA transplantation under controlled indentation. Intact cadaveric patellae (n = 4) were prepared, with three serving as recipients and one as donor. Samples were cyclically compressed in a custom-built rig using nominal displacements of 1 and 2 mm. The complex phase data were unwrapped and converted to displacements; the Green-Lagrange strain tensor was computed using a finite element framework in FEniCS. Minimum principal strain ( Results: Global displacement fields were similar between intact and OCA samples, with spherical indentation exhibiting through-thickness compression and lateral displacement in longitudinal and transverse directions. Discussion: This exploratory study provides the first experimental full volume displacement and strain distributions of patellar cartilage after OCA transplantation. The localized strain variations observed after transplantation should be interpreted descriptively, given the single-donor design and sub-physiological loading. These results establish an experimental foundation for validating computational models of the donor-recipient cartilage interaction and geometric mismatch following OCA transplantation and work investigating OCA mechanics under physiological loading.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.