Evidence map›Paper›PMID 41573303›Full record

ArticleFrontiers in human neuroscience2025

Non-linearity, complexity, and quantization concepts in biology.

Neil D Theise, Jack A Tuszynski

Abstract read
In one paragraph

Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Neil D TheiseDepartment of Pathology, NYU Grossman School of Medicine, New York, NY, United States.
Jack A TuszynskiDepartment of Mechanical and Aerospace Engineering (DIMEAS), Polytechnic University of Turin, Turin, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Founders of quantum mechanics (QM) anticipated that revisions to classical physics due to strange elements of quantum reality, would necessitate similar changes in biology. Complexity theory, systems biology and quantum biology provide possible solutions indicating that subject/object separation is a useful fiction for reductive science. Direct correlates to such QM observational/measurement issues as Complementarity and Uncertainty may justify the introduction of an analog of Heisenberg's uncertainty and the Planck constant for living systems. The phase space of "adjacent possibles" for biological systems from which one "actual" is selected resembles the collapse of the QM wave function. Since biological systems are hierarchical, this occurs across organizational scales resulting in biological coherence. The location of a quantum/classical boundary is unclear due to complexity. Whether biological systems' characteristics arise directly from QM or are of a different origin remains unsettled. To combine non-linear with quantum properties across biological scales we propose the Method of Coherent Structures (MCS), developed for quantum many-body systems. In MCS, a higher-level scale provides a classical envelope for quantum fluctuations at the lower scale. It yields a seamless transition from non-linear classical fields to quantum excitations and accounts for the emergence of complexity by incorporating metabolic energy supply.

Indexed as

biological coherenceBiological UncertaintycomplexityMethod of Coherent Structuresquantum biologysystems biology

Identifiers

PMID41573303
PMCPMC12819840

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.