ArticleFrontiers in endocrinology2025
Stc2a inhibits IGF-stimulated somatic growth in favor of organismal survival under hypoxic stress.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In response to hypoxia, animals reduce somatic growth to shift energy resources toward the maintenance of vital functions and organismal survival. Although this phenomenon is widespread, the systemic factors and mechanisms involved remain poorly understood. Here we report that hypoxia causes major changes in zebrafish transcriptomic landscapes with hormonal activity or hormonal signaling identified as most prominently up-regulated GO term and KEGG pathway. Among the top in this group is Stanniocalcin 2a (Stc2a), a secreted glycoprotein that inhibits insulin-like growth factor (IGF) signaling by binding to pappalysin metalloproteinases and inhibiting their activities. The hypoxic induction of
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