Evidence map›Paper›PMID 41573124›Full record

ArticleDepression and anxiety2026

Major Depressive Disorder With Versus Without Psychosocial Triggers: A Secondary Analysis of a Prospective Cohort Study.

Chunfeng Xiao, Shuilin Wu, Lili Shi, Tao Li, Yanping Duan, Xin Yu, Gang Wang, Gang Zhu, Kerang Zhang, Jinya Cao and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Depression and anxiety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chunfeng XiaoPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn.ORCID https://orcid.org/0000-0001-5681-6584
Shuilin WuPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn.
Lili ShiPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn.
Tao LiPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn.
Yanping DuanPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn.
Xin YuPeking University Sixth Hospital (Institute of Mental Health), Beijing, China.ORCID https://orcid.org/0000-0003-3983-4937
Gang WangBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China, ccmu.edu.cn.ORCID https://orcid.org/0000-0003-3949-1188
Gang ZhuDepartment of Psychiatry, The First Affiliated Hospital of China Medical University, Liaoning, China, cmu.edu.cn.
Kerang ZhangDepartment of Psychiatry, First Hospital of Shanxi Medical University, Shanxi Medical University, Taiyuan, Shanxi, China, sxmu.edu.cn.
Jinya CaoPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn.ORCID https://orcid.org/0000-0002-4318-2380
Jing WeiPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, cacms.ac.cn.ORCID https://orcid.org/0000-0001-8167-9075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Few studies have examined differences in symptom presentation and antidepressant response between patients with major depressive disorder (MDD) with and without psychosocial triggers. Methods: This was a secondary analysis of a multicenter, multistage prospective cohort study conducted at nine top tertiary hospitals across six provinces/municipalities in China. The cohort included patients with first-episode MDD, with or without psychosocial triggers, who received one of six selective serotonin reuptake inhibitors (SSRIs). Results: Of 359 enrolled patients with first-episode MDD, 303 (mean [SD] age, 39.6 [10.1] years; 201 [66.8%] women) were included in the final analysis. There were no significant differences in network structure ( Conclusions: While patients with MDD with and without psychosocial triggers shared broadly similar clinical profiles and SSRI responses, differences in symptom network architecture may have implications for individualized symptom monitoring and treatment strategies.

Indexed as

Major Depressive DisorderSelective Serotonin Reuptake InhibitorsAdultChinaFemaleHumansMaleMiddle AgedProspective StudiesSelective Serotonin Reuptake Inhibitors

Identifiers

PMID41573124
PMCPMC12820511

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.