Evidence map›Paper›PMID 41573071›Full record

ArticleNorthern clinics of Istanbul2025

Liver fibrosis scores can also be used as a marker of cardiovascular risk in non-alcoholic fatty liver disease.

Hanife Serife Aktas, Mahmud Esad Pence, Sibel Kuras, Sevil Ozkan, Sema Basat

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Article in Northern clinics of Istanbul, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Hanife Serife AktasDepartment of Internal Medicine, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkiye.
Mahmud Esad PenceDepartment of Medical Biochemistry, Uskudar University Faculty of Medicine, Istanbul, Turkiye.
Sibel KurasDepartment of Medical Biochemistry, University of Health Sciences, Hamidiye Faculty of Medicine, Istanbul, Turkiye.
Sevil OzkanDepartment of Internal Medicine, University of Health Sciences, Haydarpasa Training and Research Hospital, Istanbul, Turkiye.
Sema BasatDepartment of Internal Medicine, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study was designed to evaluate the relationship between Atherogenic Plasma Index (API), a cardiovascular event risk marker, and hepatic fibrosis level in non-alcoholic fatty liver disease (NAFLD) patients.

methods129 people over the age of 18 with NAFLD were included in the study. Fasting blood glucose (FBG), HOMA-IR, HbA1C, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT), albumin, triglyceride (TG), total cholesterol (TC), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), nonHDL-cholesterol (nonHDL-C), direct bilirubin, TC/HDL-C, LDL-C/HDL-C and TG/HDL-C ratios were calculated. NAFLD fibrosis score (NFS), FIB-4, APRI scores were determinated. It was classified as low, high and intermediate. The API was calculated and its relationship with the level of hepatic fibrosis was evaluated.

resultsThe API level in the high group of NFS is higher than that in the low group. Similarly, the API level in the high group of FIB-4 is higher than that in the low group. The API in the low group of APRI are lower than the ID group. There is a positive correlation between API and NFS, FIB-4, APRI scores in all NAFLD subjects. There is a positive correlation between API and NFS, FIB-4, APRI scores in all NAFLD subjects in the study.

conclusionIn this study, we found that there was a relationship between FIB-4, NFS, APRI scores, API and dyslipidemia in people with NAFLD, and that as the level of fibrosis increased, the risk of cardiovascular event also increased. Liver fibrosis scores can also be used as cardiovascular risk markers.

Indexed as

Atherogenic plasma indexFIB-4 scorenon-alcoholic fatty liver disease

Identifiers

PMID41573071
PMCPMC12821135

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