ArticleNorthern clinics of Istanbul2025
Effects of CAPE on biochemical, histopathological and cardiac parameters in doxorubicin induced cardiotoxicity.
Article in Northern clinics of Istanbul, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Evaluation of vinpocetine in an acute doxorubicin-induced cardiotoxicity model in rats.Scientific reports · 2026Article
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8 authors.
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Abstract
objectiveIn this study, the protective effect of Caffeic acid phenethyl ester (CAPE) against doxorubicin (DOX)-induced cardiotoxicity was investigated by evaluating oxidative stress parameters, ECG changes, matrix metalloproteinase 2 (MMP-2) gene expression, troponin I level and histopathology in Wistar Albino rats.
methodsForty rats were divided into 4 groups (n=10) including control (saline (vehicle for DOX) and 2.5% ethanol (vehicle for caffeic acid phenethyl ester), CAPE only (10 µmol/kg bw), DOX only (10 mg/kg bw) and CAPE+DOX groups. Molecular, biochemical and histopathological analyses were performed on blood and heart tissues.
resultsNo alterations were observed in oxidative stress parameters and MMP-2 gene expression of DOX and CAPE+DOX groups compared to control. Troponin I levels were higher in DOX and CAPE+DOX groups than in the control. Variable ECG changes were observed in the experimental groups such as increased systolic blood pressure, decreased QRS and QT interval in DOX group compared to the control without any ameliorative effect of CAPE. The presence of dense degenerative cardiomyocytes in the myocardium of the DOX group was noted. DOX caused damage to cardiomyocytes. It was observed that CAPE showed a significant decrease in histopathological changes and histopathological scoring in the CAPE+DOX group compared to DOX group.
conclusionCAPE treatment ameliorated histopathological changes induced by DOX while other parameters including oxidative stress, MMP-2 gene expression, Troponin I and ECG studied in our study were not altered remarkably.
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