Evidence map›Paper›PMID 41572999›Full record

ArticleInternational journal of ophthalmology2026

Anti-inflammatory mechanisms of

Shuo Yu, Jin-Yi Yu, Xin-Li Liu, Jing Wang, Shi-Lan Feng, Hong Lu

Abstract read
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Article in International journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuo YuDepartment of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.
Jin-Yi YuDepartment of Ophthalmology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong Province, China.
Xin-Li LiuDepartment of Ophthalmology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Jing WangDepartment of Ophthalmology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.
Shi-Lan FengSchool of Pharmacy, Lanzhou University, Lanzhou 730000, Gansu Province, China.
Hong LuDepartment of Ophthalmology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo identify key genes and inflammatory signaling pathways involved in the anti-inflammatory effects of

methodsEIU was induced in Wistar rats through subcutaneous injection of lipopolysaccharide (LPS, 200 µg) and the rats were then randomly assigned to EIU group (

resultsA total of 322 DEGs were identified, comprising 254 mRNA and 68 lncRNA genes. GO analysis revealed significant functional categories, including response to LPS. Pathway analysis identified key signaling pathways involved in uveitis, such as cytokine-cytokine receptor interactions. Notably, 16 mRNA and 7 lncRNA DEGs emerged as central nodes in the gene correlation network.

conclusionHPS exerts its anti-inflammatory effects through coordinated signaling pathways, offering insights into potential therapeutic targets for managing uveitis.

Indexed as

differentially expressed genesendotoxin-induced uveitisgene expression microarrayHedysarum polybotrys polysaccharidelncRNA

Identifiers

PMID41572999
PMCPMC12820618

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.