Evidence map›Paper›PMID 41572826›Full record

ArticlePsychological medicine2026

Network dynamics of depression, anxiety, sleep disturbances, and suicidal symptoms in Chinese adolescents: a longitudinal cross-sectional and cross-lagged panel network analysis.

Bin Sun, Jie Zhang, Yarong Ma, Hongbo He

Abstract read
In one paragraph

Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Bin SunThe Affiliated Brain Hospital, https://ror.org/00zat6v61Guangzhou Medical University, China.ORCID https://orcid.org/0000-0001-5776-5459
Jie ZhangThe Affiliated Brain Hospital, https://ror.org/00zat6v61Guangzhou Medical University, China.
Yarong Mahttps://ror.org/05c74bq69Shenzhen Second People's Hospital, China.
Hongbo Hehttps://ror.org/01vjw4z39Guangdong Provincial People's Hospital Affiliated to Southern Medical University, China.

Funding

Medical Science and Technology Foundation of Guangdong Province 2021A1515111206Natural Science Foundation of Guangdong Province 2024A1515013133
6 · The paper itself

Abstract

backgroundDepression in adolescents involves complex interactions among depression, anxiety, sleep disturbances, and suicidal symptoms. Network theory offers insights into dynamic symptom relationships during recovery.

methodsOf 797 adolescents initially enrolled, 649 with complete baseline data were included in the network analyses; 458 and 277 participants were retained at the 1-month and 3-month follow-ups, respectively. Cross-sectional Gaussian Graphical Models and Cross-Lagged Panel Network (CLPN) analyses examined relationships among nine symptom domains: depression, somatic/subjective anxiety, sleep quantity/quality, daytime insomnia, passive/active sleepiness, and suicidal ideation/tendency. Network centrality and bootstrap validation assessed parameter stability.

resultsCross-sectional networks showed structural invariance across timepoints (p>0.05). Subjective anxiety demonstrated highest centrality at T0-T1, while somatic symptoms dominated at T2. Depression maintained high closeness centrality throughout. Although betweenness centrality also suggested a central role for depression, its lower stability (CS < 0.5) necessitates a more cautious interpretation of this specific metric. CLPN revealed more predictive relationships during T0→T1 (76.5% significant edges) than T1→T2 (24.7%). Active sleepiness strongly predicted subsequent somatic anxiety (B=0.683) and depression (B=0.647). Suicide ideation-tendency showed stable bidirectional connections. Network stability was excellent (CS>0.5) except betweenness centrality.

conclusionsCentral symptoms evolved during recovery, with subjective anxiety initially dominant but somatic symptoms becoming central over time. The early post-treatment period showed heightened symptom network activity, with sleep disturbances identified as robust predictors of subsequent affective deterioration. Findings support dynamic, network-informed interventions targeting evolving symptom centrality and predictive pathways, particularly addressing sleep-related symptoms and suicide risk during critical recovery phases.

Indexed as

AnxietyDepressionSleep Wake DisordersSuicidal IdeationAdolescentChinaCross-Sectional StudiesEast Asian PeopleFemaleHumansLongitudinal StudiesMaleadolescent mental healthcross-lagged panel networkdepression networkssleep disturbancessuicidal ideation

Identifiers

PMID41572826
PMCPMC12885338

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.