ArticleDialogues in clinical neuroscience2026
Association of sexual dysfunctions according to DSM-5 criteria with structural brain differences in women and men from the Hamburg City Health Study.
Article in Dialogues in clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionSexual dysfunctions are prevalent public health issues with understudied neurobiological correlates. This study explores structural brain differences in individuals with DSM-5 sexual dysfunctions vs. matched controls.
methodsThis cross-sectional study employed voxel-based morphometry (VBM) to analyse structural brain scans from the Hamburg City Health Study. Participants with erectile disorder (ED;
resultsED showed clusters in right putamen with reduced rGMV and left postcentral gyrus with higher rGMV. PE displayed lower rGMV in cerebellar lobe VI/Crus I and left superior/medial temporal gyrus. GPPPD exhibited higher rGMV in right middle frontal gyrus. FSIAD showed no differences. No clusters survived FDR correction, underscoring the exploratory and hypothesis-generating nature of the reported findings.
conclusionsThis study identifies potential associations between sexual dysfunctions and structural brain differences in regions related to sexual function, arousal, inhibition, motor coordination, and pain processing. Results require cautious interpretation due to small sample sizes, but provide hypothesis-generating evidence for future research .
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