Evidence map›Paper›PMID 41572658›Full record

ArticleThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi2026

Stool DNA-based SDC2 Methylation Test for the Screening of Colorectal Neoplasia in an Asymptomatic, Average-Risk Population.

Hyoung Il Choi, Jae Myung Cha, Young Sang Kim, Dae Hyeon Cho, Han Ju Pack, Soo-Young Na, Ji Hye Kim, Hyun Gun Kim, Young-Jin Park, Hye Jung Kwon and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hyoung Il ChoiDepartment of Internal Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
Jae Myung ChaDepartment of Internal Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea.ORCID 0000-0001-9403-230X
Young Sang KimDepartment of Family Medicine, CHA Bundang Medical Center, CHA University, Seoul, Korea.
Dae Hyeon ChoDepartment of Internal Medicine, Samsung Changwon Hospital, Sungkyunkwan University of Medicine, Changwon, Korea.
Han Ju PackDepartment of Family Medicine, Yuseong Sun Hospital, Daejeon, Korea.
Soo-Young NaDepartment of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.
Ji Hye KimDepartment of Health Promotion, Severance Check-Up, Yonsei University Health System, Seoul, Korea.
Hyun Gun KimDepartment of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea.
Young-Jin ParkDepartment of Family Medicine, Dong-A University College of Medicine, Dong-A University Medical Center, Busan, Korea.
Hye Jung KwonDepartment of Internal Medicine, Ilsin Christian Hospital, Busan, Korea.
Kyeong Ok KimDepartment of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.
Geon Ho LeeDepartment of Family Medicine, Daegu Catholic University Medical Center, Daegu, Korea.
Yoo Jin LeeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: Programmatic screening for colorectal cancer (CRC) could maximize the impact of screening in the average-risk population, but the diagnostic performance of a stool DNA-based Methods: This retrospective, multicenter study included consecutive asymptomatic, average-risk individuals for CRC who completed a Results: Over 54 months, 4,910 individuals completed the Conclusions: A stool DNA-based meSDC2 test in average-risk individuals for CRC revealed a high PPV for any CRN in a real-world setting, highlighting its potential as a screening modality in programmatic CRC screening.

Indexed as

Colorectal NeoplasmsDNA MethylationFecesSyndecan-2AdultAgedColonoscopyEarly Detection of CancerFemaleHumansMaleMiddle AgedPredictive Value of TestsRetrospective StudiesROC CurveSDC2 protein, humanSyndecan-2BiomarkersColorectal neoplasmsDNA methylationFecesMass screening

Identifiers

PMID41572658
PMCPMC12834636

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.