ArticlePest management science2026
Peptidic product derived from trypsin autolysis modulates insect digestive proteases and supports plant biochemical defense.
Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- An Autolysis-Derived Trypsin Peptide Disrupts Digestive Homeostasis and Reduces Fitness inACS omega · 2026Article
- Structure-Guided Design of an Interface-Derived Inhibitor Peptide Against Spodoptera frugiperda Digestive Trypsins.Archives of insect biochemistry and physiology · 2026Article
- Synthetic Peptide Inhibition of Trypsin-Like Proteases in Spodoptera frugiperda (Lepidoptera: Noctuidae): Evaluating the Influence of Gut Microbiota.Archives of insect biochemistry and physiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundSpodoptera frugiperda, commonly known as the fall armyworm, is a highly economically significant pest that affects various crops, resulting in substantial losses in productivity. Managing this pest primarily relies on chemical insecticides; however, the repeated development of resistance to these chemicals has rendered them less effective. Given this scenario, sustainable alternatives, such as the use of digestive enzyme inhibitors, have been investigated as potential tools in pest management.
resultsMolecular docking predicts a conserved, isoform-spanning pose for GORE 3 on S. frugiperda trypsins, with occupancy of S1/S1' and adjacent subsites and richer aromatic/hydrophobic contacts than the S1-focused reference benzamidine. This binding topology aligns with the enzymology: GORE 3 acts as a competitive inhibitor (K
conclusionDocking and bioassays collectively demonstrate that GORE 3 interacts with trypsin-like proteases through a robust, multisite binding mode, resulting in competitive inhibition and measurable physiological effects in S. frugiperda. Although less potent than benzamidine based on K
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.