Evidence map›Paper›PMID 41572631›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2026

CD8

Dawei Zou, Stephanie G Yi, Yulin Dai, Luan Truong, Lillian W Gaber, Richard J Knight, Xiang Xiao, Rafik M Ghobrial, Xian C Li, Zhongming Zhao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. NK-like and networked CD8bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dawei ZouImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College, New York, NY 10065, USA.
Stephanie G YiImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX 77030, USA; J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Surgery, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: sgyi@houstonmethodist.org.
Yulin DaiCenter for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Luan TruongDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
Lillian W GaberDepartment of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
Richard J KnightJ.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Surgery, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College, New York, NY 10065, USA.
Xiang XiaoImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College, New York, NY 10065, USA.
Rafik M GhobrialJ.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Surgery, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College, New York, NY 10065, USA.
Xian C LiImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College, New York, NY 10065, USA.
Zhongming ZhaoCenter for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA; The University of Texas MD Anderson Cancer Center, UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX 77030, USA. Electronic address: zhongming.zhao@uth.tmc.edu.
Wenhao ChenImmunobiology & Transplant Science Center, Houston Methodist Research Institute, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College, New York, NY 10065, USA. Electronic address: wchen@houstonmethodist.org.
A Osama GaberJ.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Surgery, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Surgery, Weill Cornell Medical College, New York, NY 10065, USA.

Funding

Transforming dbGaP genetic and genomic data to FAIR-ready by artificial intelligence and machine learning algorithmsR01LM012806 · NLM · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Zhongming Zhao · 2017 to 2026
$3.7M
Impact of Irreversible T Cell Dysfunction on Transplant OutcomesR56AI132492 · NIAID · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHEN, WENHAO · 2024 to 2024
$323k
NIAID NIH HHS R56 AI132492NLM NIH HHS R01 LM012806
6 · The paper itself

Abstract

T cells are central drivers of transplant rejection, yet the differentiation fates underlying this process remain unclear. Using single-cell transcriptomic profiling of human kidney allograft biopsies, we identified a predominant infiltrating CD8

Indexed as

CD8-Positive T-LymphocytesCell DifferentiationGraft RejectionKidney TransplantationKiller Cells, NaturalAnimalsBiomarkersGene Expression ProfilingHumansInterferon Regulatory Factor-4Interferon Regulatory FactorsMiceTOR Serine-Threonine KinasesBiomarkersInterferon Regulatory Factor-4Interferon Regulatory FactorsTOR Serine-Threonine KinasesCD8(+) T cell differentiationcostimulation blockadeIRF4kidney transplantationNK-likerapamycinscRNA-seqT celltransplant rejection

Identifiers

PMID41572631
PMCPMC12967240

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.