Evidence map›Paper›PMID 41572610›Full record

ArticleACS applied bio materials2026

Sustainable Silk Fibroin Nanofibers Membranes with Natural Photothermal and Bioactive Components for Adhesive-Free Soft Tissue Repair.

Martina Corsini, Livia Ottaviano, Luana Mariani, Marianna Barbalinardo, Giada Magni, Francesca Rossi, Fulvio Ratto, Anna Donnadio, Roberto Zamboni, Annalisa Aluigi and 2 more

Abstract read
In one paragraph

Article in ACS applied bio materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Martina CorsiniConsiglio Nazionale delle Ricerche, Istituto per la Sintesi Organica e la Fotoreattività (CNR-ISOF), via Piero Gobetti 101, 40129 Bologna, Italy.
Livia OttavianoConsiglio Nazionale delle Ricerche, Istituto per la Sintesi Organica e la Fotoreattività (CNR-ISOF), via Piero Gobetti 101, 40129 Bologna, Italy.
Luana MarianiConsiglio Nazionale delle Ricerche, Istituto per la Sintesi Organica e la Fotoreattività (CNR-ISOF), via Piero Gobetti 101, 40129 Bologna, Italy.
Marianna BarbalinardoConsiglio Nazionale delle Ricerche, Istituto per lo Studio dei Materiali Nanostrutturati (CNR-ISMN), via Piero Gobetti 101, 40129 Bologna, Italy.ORCID 0000-0002-2143-2860
Giada MagniConsiglio Nazionale delle Ricerche Istituto di Fisica Applicata Nello Carrara (CNR-IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy.ORCID 0000-0003-2736-9150
Francesca RossiConsiglio Nazionale delle Ricerche Istituto di Fisica Applicata Nello Carrara (CNR-IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy.
Fulvio RattoConsiglio Nazionale delle Ricerche Istituto di Fisica Applicata Nello Carrara (CNR-IFAC), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy.ORCID 0000-0001-6721-9486
Anna DonnadioDipartimento di Scienze Farmaceutiche, Università di Perugia, Via del Liceo, 1, 06123 Perugia, Italy.ORCID 0000-0003-2903-4135
Roberto ZamboniConsiglio Nazionale delle Ricerche, Istituto per la Sintesi Organica e la Fotoreattività (CNR-ISOF), via Piero Gobetti 101, 40129 Bologna, Italy.
Annalisa AluigiDipartimento di Scienze Biomolecolari, Università di Urbino, Piazza del Rinascimento 6, 61029 Urbino, Italy.ORCID 0000-0001-8754-7161
Giovanna SotgiuConsiglio Nazionale delle Ricerche, Istituto per la Sintesi Organica e la Fotoreattività (CNR-ISOF), via Piero Gobetti 101, 40129 Bologna, Italy.ORCID 0000-0003-3590-714X
Tamara PosatiConsiglio Nazionale delle Ricerche, Istituto per la Sintesi Organica e la Fotoreattività (CNR-ISOF), via Piero Gobetti 101, 40129 Bologna, Italy.ORCID 0000-0002-3879-266X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multifunctional silk fibroin (SF) nanofibrous membranes incorporating cuttlefish ink (CI) and vitamin B2 (VitB2) were developed via water-based electrospinning as bioactive scaffolds for soft tissue regeneration and laser-assisted tissue welding. CI provided antioxidant and photothermal properties, while VitB2 promoted cellular proliferation. Membranes exhibited controlled VitB2 release and CI retention within the matrix. NIH-3T3 fibroblast assays confirmed high viability (>80% at 48 h), with CI promoting adhesion and cytoskeletal organization, and VitB2 enabling formation of a confluent, organized cell layer. Laser-assisted welding produced satisfactory adhesion and shear-stress resistance on the order of ten kPa in ex vivo tendons, corneas, and sclerae, while keeping tissue temperatures below the 60 °C threshold for thermal damage. These findings highlight CI- and VitB2-loaded SF membranes as sustainable, cytocompatible scaffolds with antioxidant and adhesive functionalities, offering a versatile platform for soft tissue repair via an adhesive-free approach.

Indexed as

Biocompatible MaterialsFibroinsNanofibersAnimalsMiceRiboflavinTissue ScaffoldsWound HealingBiocompatible MaterialsFibroinsRiboflavinadhesive free tissue repaircuttlefish inknanofiberssilk fibroinvitamin B2

Identifiers

PMID41572610
PMCPMC12914641

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.